MaGIC: a machine learning tool set and web application for monoallelic gene inference from chromatin.
Journal:
BMC bioinformatics
PMID:
30819107
Abstract
BACKGROUND: A large fraction of human and mouse autosomal genes are subject to random monoallelic expression (MAE), an epigenetic mechanism characterized by allele-specific gene expression that varies between clonal cell lineages. MAE is highly cell-type specific and mapping it in a large number of cell and tissue types can provide insight into its biological function. Its detection, however, remains challenging.