Localizing epileptogenic regions using high-frequency oscillations and machine learning.

Journal: Biomarkers in medicine
Published Date: May 2, 2019

Abstract

Pathological high frequency oscillations (HFOs) are putative neurophysiological biomarkers of epileptogenic brain tissue. Utilizing HFOs for epilepsy surgery planning offers the promise of improved seizure outcomes for patients with medically refractory epilepsy. This review discusses possible machine learning strategies that can be applied to HFO biomarkers to better identify epileptogenic regions. We discuss the role of HFO rate, and utilizing features such as explicit HFO properties (spectral content, duration, and power) and phase-amplitude coupling for distinguishing pathological HFO (pHFO) events from physiological HFO events. In addition, the review highlights the importance of neuroanatomical localization in machine learning strategies.

Authors

  • Shennan A Weiss
    Departments of Neurology & Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA.
  • Zachary Waldman
    Departments of Neurology & Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA.
  • Federico Raimondo
    Department of Computer Science, Faculty of Exact & Natural Sciences, University of Buenos Aires, Buenos Aires, Argentina.
  • Diego Slezak
    Department of Computer Science, Faculty of Exact & Natural Sciences, University of Buenos Aires, Buenos Aires, Argentina.
  • Mustafa Donmez
    Departments of Neurology & Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA.
  • Gregory Worrell
  • Anatol Bragin
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
  • Jerome Engel
    Department of Neurology, David Geffen School of Medicine and at UCLA, Los Angeles, CA 90095, United States; Department of Neurosurgery, David Geffen School of Medicine and at UCLA, Los Angeles, CA 90095, United States; Department of Neurobiology, David Geffen School of Medicine and at UCLA, Los Angeles, CA 90095, United States; Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine and at UCLA, Los Angeles, CA 90095, United States.
  • Richard Staba
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
  • Michael Sperling
    Departments of Neurology & Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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