Identification of clathrin proteins by incorporating hyperparameter optimization in deep learning and PSSM profiles.

Journal: Computer methods and programs in biomedicine
Published Date: Aug 1, 2019

Abstract

BACKGROUND AND OBJECTIVES: Clathrin is an adaptor protein that serves as the principal element of the vesicle-coating complex and is important for the membrane cleavage to dispense the invaginated vesicle from the plasma membrane. The functional loss of clathrins has been tied to a lot of human diseases, i.e., neurodegenerative disorders, cancer, Alzheimer's diseases, and so on. Therefore, creating a precise model to identify its functions is a crucial step towards understanding human diseases and designing drug targets.

Authors

  • Nguyen Quoc Khanh Le
    In-Service Master Program in Artificial Intelligence in Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan; AIBioMed Research Group, Taipei Medical University, Taipei 110, Taiwan; Translational Imaging Research Center, Taipei Medical University Hospital, Taipei 110, Taiwan. Electronic address: khanhlee@tmu.edu.tw.
  • Tuan-Tu Huynh
    Department of Electrical Electronic and Mechanical Engineering, Lac Hong University, No. 10 Huynh Van Nghe Road, Bien Hoa, Dong Nai, Vietnam.
  • Edward Kien Yee Yapp
    Singapore Institute of Manufacturing Technology, 2 Fusionopolis Way, #08-04, Innovis, 138634, Singapore.
  • Hui-Yuan Yeh
    School of Humanities, Nanyang Technological University, 14 Nanyang Dr, Singapore 637332.

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