Improving prediction of phenotypic drug response on cancer cell lines using deep convolutional network.

Journal: BMC bioinformatics
Published Date: Jul 29, 2019

Abstract

BACKGROUND: Understanding the phenotypic drug response on cancer cell lines plays a vital role in anti-cancer drug discovery and re-purposing. The Genomics of Drug Sensitivity in Cancer (GDSC) database provides open data for researchers in phenotypic screening to build and test their models. Previously, most research in these areas starts from the molecular fingerprints or physiochemical features of drugs, instead of their structures.

Authors

  • Pengfei Liu
    Department of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
  • Hongjian Li
    Department of Computer Science and Engineering, Chinese University of Hong Kong, Hong Kong, China.
  • Shuai Li
    School of Molecular Biosciences, Center for Reproductive Biology, College of Veterinary Medicine, Washington State University.
  • Kwong-Sak Leung
    Department of Computer Science and Engineering, Chinese University of Hong Kong, Hong Kong, China.

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