Assessment of lipid peroxidation and artificial neural network models in early Alzheimer Disease diagnosis.

Journal: Clinical biochemistry
Published Date: Oct 1, 2019

Abstract

OBJECTIVE: Lipid peroxidation constitutes a molecular mechanism involved in early Alzheimer Disease (AD) stages, and artificial neural network (ANN) analysis is a promising non-linear regression model, characterized by its high flexibility and utility in clinical diagnosis. ANN simulates neuron learning procedures and it could provide good diagnostic performances in this complex and heterogeneous disease compared with linear regression analysis.

Authors

  • Carmen Peña-Bautista
    Neonatal Research Unit, Health Research Institute La Fe, Valencia, Spain.
  • Thierry Durand
    Institut des Biomolécules Max Mousseron, IBMM, University of Montpellier, CNRS ENSCM, Montpellier, France.
  • Camille Oger
    Institut des Biomolécules Max Mousseron, IBMM, University of Montpellier, CNRS ENSCM, Montpellier, France.
  • Miguel Baquero
    Neurology Unit, University and Polytechnic Hospital La Fe, Valencia, Spain.
  • Máximo Vento
    Neonatal Research Unit, Health Research Institute La Fe, Valencia, Spain.
  • Consuelo Cháfer-Pericás
    Neonatal Research Unit, Health Research Institute La Fe, Valencia, Spain. Electronic address: m.consuelo.chafer@uv.es.

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