Development and validation of a sensitive and high throughput UPLC-MS/MS method for determination of paraquat and diquat in human plasma and urine: application to poisoning cases at emergency departments of hospitals.

Journal: Forensic toxicology
PMID: 36454496

Abstract

PURPOSE: Paraquat and diquat are well-known toxic herbicides, at least responsible for hundreds of fatal poisoning events worldwide. However, the determination of diquat and paraquat in plasma and urine is very challenging because of their high polarity and double charge characteristics. In this study, we aim to develop a rapid and reliable method for the determination of paraquat and diquat in human plasma and urine by ultraperformance liquid chromatography-tandem mass spectrometry.

Authors

  • Zhengsheng Mao
    Department of Forensic Medicine, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's Republic of China. maozhengsheng@njmu.edu.cn.
  • Youjia Yu
    Department of Forensic Medicine, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's Republic of China.
  • Hao Sun
    Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin, China.
  • Weirang Xie
    Department of Forensic Medicine, Nanjing Medical University, Nanjing, Jiangsu, 211166, People's Republic of China.
  • Hongmei Zhao
    Department of Emergency Medicine, Huaian First People's Hospital, Huaian, China.
  • Qiaoyan Jiang
    Department of Forensic Medicine, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's Republic of China.
  • Yang Sun
    Department of Gastroenterology, First Affiliated Hospital of Kunming Medical University, Kunming, China.
  • Yue Cao
    Department of Forensic Medicine, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's Republic of China.
  • Feng Chen
    Department of Integrated Care Management Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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