Artificial intelligence predicts the progression of diabetic kidney disease using big data machine learning.

Journal: Scientific reports
Published Date:

Abstract

Artificial intelligence (AI) is expected to support clinical judgement in medicine. We constructed a new predictive model for diabetic kidney diseases (DKD) using AI, processing natural language and longitudinal data with big data machine learning, based on the electronic medical records (EMR) of 64,059 diabetes patients. AI extracted raw features from the previous 6 months as the reference period and selected 24 factors to find time series patterns relating to 6-month DKD aggravation, using a convolutional autoencoder. AI constructed the predictive model with 3,073 features, including time series data using logistic regression analysis. AI could predict DKD aggravation with 71% accuracy. Furthermore, the group with DKD aggravation had a significantly higher incidence of hemodialysis than the non-aggravation group, over 10 years (N = 2,900). The new predictive model by AI could detect progression of DKD and may contribute to more effective and accurate intervention to reduce hemodialysis.

Authors

  • Masaki Makino
    Department of Endocrinology and Metabolism, Fujita Health University, Toyoake, Aichi, Japan.
  • Ryo Yoshimoto
    Department of Endocrinology and Metabolism, Fujita Health University, Toyoake, Aichi, Japan.
  • Masaki Ono
    IBM Research, Tokyo, Japan.
  • Toshinari Itoko
    IBM Research, Tokyo, Japan.
  • Takayuki Katsuki
    IBM Research, Tokyo, Japan.
  • Akira Koseki
    IBM Research, Tokyo, Japan.
  • Michiharu Kudo
    IBM Research, Tokyo, Japan.
  • Kyoichi Haida
    Business Process Planning Department, The Dai-ichi Life Insurance Company, Limited, Tokyo, Japan.
  • Jun Kuroda
    IT Business Process Planning Department, The Dai-ichi Life Insurance Company, Limited, Tokyo, Japan.
  • Ryosuke Yanagiya
    Division of Medical Information Systems, Fujita Health University, Toyoake, Aichi, Japan.
  • Eiichi Saitoh
    Department of Rehabilitation Medicine I, School of Medicine, Fujita Health University, Toyoake, Japan.
  • Kiyotaka Hoshinaga
    Department of Urology, Fujita Health University, Toyoake, Aichi, Japan.
  • Yukio Yuzawa
    Department of Nephrology, Fujita Health University, Toyoake, Aichi, Japan.
  • Atsushi Suzuki
    Department of Endocrinology and Metabolism, Fujita Health University, Toyoake, Aichi, Japan. aslapin@fujita-hu.ac.jp.