A comparison of machine learning techniques for classification of HIV patients with antiretroviral therapy-induced mitochondrial toxicity from those without mitochondrial toxicity.

Journal: BMC medical research methodology
Published Date: Nov 27, 2019

Abstract

BACKGROUND: Antiretroviral therapy (ART) has significantly reduced HIV-related morbidity and mortality. However, therapeutic benefit of ART is often limited by delayed drug-associated toxicity. Nucleoside reverse transcriptase inhibitors (NRTIs) are the backbone of ART regimens. NRTIs compete with endogenous deoxyribonucleotide triphosphates (dNTPs) in incorporation into elongating DNA chain resulting in their cytotoxic or antiviral effect. Thus, the efficacy of NRTIs could be affected by direct competition with endogenous dNTPs and/or feedback inhibition of their metabolic enzymes. In this paper, we assessed whether the levels of ribonucleotides (RN) and dNTP pool sizes can be used as biomarkers in distinguishing between HIV-infected patients with ART-induced mitochondrial toxicity and HIV-infected patients without toxicity.

Authors

  • Jong Soo Lee
    Department of Mathematical Sciences, University of Massachusetts, Lowell, MA, USA.
  • Elijah Paintsil
    Department of Pediatrics, Yale University, New Haven, CT, USA.
  • Vivek Gopalakrishnan
    Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, USA.
  • Musie Ghebremichael
    Ragon Institute of Harvard, MGH and MIT, 400 Technology Square, Cambridge, MA, 02129, USA. musie_ghebremichael@dfci.harvard.edu.

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