AIMC Topic: Ribonucleotides

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Liposome-encapsulated AICAR hydrogel regulates macrophage metabolic reprogramming via SIK1 activation to alleviate osteoarthritis.

Journal of nanobiotechnology Jul 5, 2025
BACKGROUND: Osteoarthritis (OA), the most prevalent joint disorder, is characterized by a complex etiology and a lack of safe and effective therapeutic interventions. Emerging evidence suggests that immune cell dysregulation plays a pivotal role in t...
Humans Osteoarthritis Hydrogels Lipid Metabolism Mice Ribonucleotides Metabolic Reprogramming Aminoimidazole Carboxamide Mice, Inbred C57BL Liposomes Protein Serine-Threonine Kinases RAW 264.7 Cells Animals Male Macrophages
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A comparison of machine learning techniques for classification of HIV patients with antiretroviral therapy-induced mitochondrial toxicity from those without mitochondrial toxicity.

BMC medical research methodology Nov 27, 2019
BACKGROUND: Antiretroviral therapy (ART) has significantly reduced HIV-related morbidity and mortality. However, therapeutic benefit of ART is often limited by delayed drug-associated toxicity. Nucleoside reverse transcriptase inhibitors (NRTIs) are ...
HIV Infections Anti-Retroviral Agents Case-Control Studies Dideoxynucleotides Deoxyribonucleotides Ribonucleotides Humans Machine Learning Algorithms Biomarkers
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PRIdictor: Protein-RNA Interaction predictor.

Bio Systems Dec 1, 2015
Several computational methods have been developed to predict RNA-binding sites in protein, but its inverse problem (i.e., predicting protein-binding sites in RNA) has received much less attention. Furthermore, most methods that predict RNA-binding si...
Binding Sites Ribonucleotides RNA Computational Biology Proteins Support Vector Machine Amino Acids
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Application of artificial neural network to investigate the effects of 5-fluorouracil on ribonucleotides and deoxyribonucleotides in HepG2 cells.

Scientific reports Nov 18, 2015
Endogenous ribonucleotides and deoxyribonucleotides are essential metabolites that play important roles in a broad range of key cellular functions. Their intracellular levels could also reflect the action of nucleoside analogues. We investigated the ...
Adenine Nucleotides Cytosine Nucleotides Deoxyribonucleotides Guanine Nucleotides Tandem Mass Spectrometry Inhibitory Concentration 50 Fluorouracil Thymine Nucleotides Uracil Nucleotides Ribonucleotides Neural Networks, Computer Hep G2 Cells Metabolic Networks and Pathways Cell Survival Models, Biological Humans Chromatography, Liquid
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Machine Learning-Augmented Molecular Dynamics Simulations (MD) Reveal Insights Into the Disconnect Between Affinity and Activation of ZTP Riboswitch Ligands.

Angewandte Chemie (International ed. in English) Jul 28, 2025
The challenge of targeting RNA with small molecules necessitates a better understanding of RNA-ligand interaction mechanisms. However, the dynamic nature of nucleic acids, their ligand-induced stabilization, and how conformational changes influence g...
Nucleic Acid Conformation Molecular Dynamics Simulation Machine Learning Ribonucleotides Riboswitch Ligands Aminoimidazole Carboxamide
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