Enabling Technologies for Personalized and Precision Medicine.

Journal: Trends in biotechnology
Published Date: May 1, 2020

Abstract

Individualizing patient treatment is a core objective of the medical field. Reaching this objective has been elusive owing to the complex set of factors contributing to both disease and health; many factors, from genes to proteins, remain unknown in their role in human physiology. Accurately diagnosing, monitoring, and treating disorders requires advances in biomarker discovery, the subsequent development of accurate signatures that correspond with dynamic disease states, as well as therapeutic interventions that can be continuously optimized and modulated for dose and drug selection. This work highlights key breakthroughs in the development of enabling technologies that further the goal of personalized and precision medicine, and remaining challenges that, when addressed, may forge unprecedented capabilities in realizing truly individualized patient care.

Authors

  • Dean Ho
    The N.1 Institute for Health (N.1), National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore.
  • Stephen R Quake
    Department of Bioengineering, Stanford University, CA, USA; Department of Applied Physics, Stanford University, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA.
  • Edward R B McCabe
    March of Dimes Foundation, New York, USA. Electronic address: emccabe@mednet.ucla.edu.
  • Wee Joo Chng
    Department of Haematology and Oncology, National University Cancer Institute, National University Health System, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
  • Edward K Chow
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
  • Xianting Ding
    2 Mechanical Engineering, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
  • Bruce D Gelb
    Mindich Child Health and Development Institute, Departments of Pediatrics and Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, NY, USA.
  • Geoffrey S Ginsburg
    Center for Applied Genomics and Precision Medicine, Duke University, NC, USA.
  • Jason Hassenstab
    Department of Neurology, Washington University in St. Louis, MO, USA; Psychological & Brain Sciences, Washington University in St. Louis, MO, USA.
  • Chih-Ming Ho
    1 School of Biomedical Engineering, Institute for Personalized Medicine, Shanghai Jiao Tong University, Shanghai, China.
  • William C Mobley
    Alzheimer's Disease Cooperative Study, Department of Neurosciences, University of California San Diego School of Medicine, La Jolla, CA, USA.
  • Garry P Nolan
    Department of Microbiology & Immunology, Stanford University, CA, USA.
  • Steven T Rosen
    Comprehensive Cancer Center and Beckman Research Institute, City of Hope, CA, USA.
  • Patrick Tan
    Duke-NUS Medical School, National University of Singapore, Singapore.
  • Yun Yen
    College of Medical Technology, Center of Cancer Translational Research, Taipei Cancer Center of Taipei Medical University, Taipei, Taiwan.
  • Ali Zarrinpar
    Department of Surgery, Division of Transplantation & Hepatobiliary Surgery, University of Florida, FL, USA.

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