An unsupervised learning approach to identify novel signatures of health and disease from multimodal data.

Journal: Genome medicine
Published Date:

Abstract

BACKGROUND: Modern medicine is rapidly moving towards a data-driven paradigm based on comprehensive multimodal health assessments. Integrated analysis of data from different modalities has the potential of uncovering novel biomarkers and disease signatures.

Authors

  • Ilan Shomorony
    Human Longevity, Inc., San Diego, CA, 92121, USA.
  • Elizabeth T Cirulli
    Human Longevity, Inc., San Diego, CA, 92121, USA.
  • Lei Huang
    School of Computer Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China.
  • Lori A Napier
    Human Longevity, Inc., San Diego, CA, 92121, USA.
  • Robyn R Heister
    Human Longevity, Inc., San Diego, CA, 92121, USA.
  • Michael Hicks
    Human Longevity, Inc., San Diego, CA, 92121, USA.
  • Isaac V Cohen
    Human Longevity, Inc., San Diego, CA, 92121, USA.
  • Hung-Chun Yu
    Human Longevity, Inc., San Diego, CA, 92121, USA.
  • Christine Leon Swisher
    Human Longevity, Inc., San Diego, CA, 92121, USA.
  • Natalie M Schenker-Ahmed
    Human Longevity, Inc., San Diego, CA, 92121, USA.
  • Weizhong Li
    Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 500040, China.
  • Karen E Nelson
    J. Craig Venter Institute, 9605 Medical Center Drive, Suite 150, Rockville, MD, 20850, USA.
  • Pamila Brar
    Human Longevity, Inc., San Diego, CA, 92121, USA.
  • Andrew M Kahn
    Human Longevity, Inc., San Diego, CA, 92121, USA.
  • Timothy D Spector
    Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
  • C Thomas Caskey
    Human Longevity, Inc., San Diego, CA, 92121, USA.
  • J Craig Venter
    Synthetic Genomics, Inc., La Jolla, California, USA.
  • David S Karow
    Human Longevity, Inc., San Diego, CA, 92121, USA.
  • Ewen F Kirkness
    Human Longevity, Inc., San Diego, CA, 92121, USA.
  • Naisha Shah
    Human Longevity, Inc., San Diego, CA, 92121, USA. naishas@gmail.com.