External Validation of PATHFx Version 3.0 in Patients Treated Surgically and Nonsurgically for Symptomatic Skeletal Metastases.

Journal: Clinical orthopaedics and related research
PMID: 32195761

Abstract

BACKGROUND: PATHFx is a clinical decision-support tool based on machine learning capable of estimating the likelihood of survival after surgery for patients with skeletal metastases. The applicability of any machine-learning tool depends not only on successful external validation in unique patient populations but also on remaining relevant as more effective systemic treatments are introduced. With advancements in the treatment of metastatic disease, it is our responsibility to patients to ensure clinical support tools remain contemporary and accurate.

Authors

  • Ashley B Anderson
    A. B. Anderson, J. A. Forsberg, Department of Surgery, Division of Orthopaedics, Walter Reed National Military Medical Center, Bethesda, MD, USA.
  • Rikard Wedin
    R. Wedin, Department of Molecular Medicine and Surgery, K1, Orthopaedics, Karolinska Institutet, Stockholm, Sweden.
  • Nicola Fabbri
    P. Boland, N. Fabbri, J. Healey, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Patrick Boland
    P. Boland, N. Fabbri, J. Healey, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • John Healey
    P. Boland, N. Fabbri, J. Healey, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Jonathan A Forsberg
    A. B. Anderson, J. A. Forsberg, Department of Surgery, Division of Orthopaedics, Walter Reed National Military Medical Center, Bethesda, MD, USA.

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