Brain morphological changes in hypokinetic dysarthria of Parkinson's disease and use of machine learning to predict severity.

Journal: CNS neuroscience & therapeutics
Published Date: Jul 1, 2020

Abstract

BACKGROUND: Up to 90% of patients with Parkinson's disease (PD) eventually develop the speech and voice disorder referred to as hypokinetic dysarthria (HD). However, the brain morphological changes associated with HD have not been investigated. Moreover, no reliable model for predicting the severity of HD based on neuroimaging has yet been developed.

Authors

  • Yingchuan Chen
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
  • Guanyu Zhu
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
  • Defeng Liu
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
  • Yuye Liu
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
  • Tianshuo Yuan
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
  • Xin Zhang
    First Department of Infectious Diseases, The First Affiliated Hospital of China Medical University, Shenyang, China.
  • Yin Jiang
    Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
  • Tingting Du
    Department of Radiation Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
  • Jianguo Zhang
    College of Automation, Harbin Engineering University, No. 145, Nantong street, Harbin, China.

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