Translating big data to better treatment in bipolar disorder - a manifesto for coordinated action.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
PMID: 32536571

Abstract

Bipolar disorder (BD) is a major healthcare and socio-economic challenge. Despite its substantial burden on society, the research activity in BD is much smaller than its economic impact appears to demand. There is a consensus that the accurate identification of the underlying pathophysiology for BD is fundamental to realize major health benefits through better treatment and preventive regimens. However, to achieve these goals requires coordinated action and innovative approaches to boost the discovery of the neurobiological underpinnings of BD, and rapid translation of research findings into development and testing of better and more specific treatments. To this end, we here propose that only a large-scale coordinated action can be successful in integrating international big-data approaches with real-world clinical interventions. This could be achieved through the creation of a Global Bipolar Disorder Foundation, which could bring government, industry and philanthropy together in common cause. A global initiative for BD research would come at a highly opportune time given the seminal advances promised for our understanding of the genetic and brain basis of the disease and the obvious areas of unmet clinical need. Such an endeavour would embrace the principles of open science and see the strong involvement of user groups and integration of dissemination and public involvement with the research programs. We believe the time is right for a step change in our approach to understanding, treating and even preventing BD effectively.

Authors

  • Mirko Manchia
    Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
  • Eduard Vieta
    CIBER Salud Mental (CIBERSAM), Madrid, Spain.
  • Olav B Smeland
    NORMENT, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
  • Cara Altimus
    Milken Institute, New York, US.
  • Andreas Bechdolf
    Vivantes Klinikum im Friedrichshain, Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Charité-Universitätsmedizin, Berlin, Germany; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany; ORYGEN, The National Centre of Excellence in Youth Mental Health, Melbourne, Victoria, Australia.
  • Frank Bellivier
    Université de Paris and INSERM UMRS 1144, Paris, France; AP-HP, Groupe Hospitalo-Universitaire AP-HP Nord, Hopital Fernand Widal, DMU Neurosciences, Département de Psychiatrie et de Médecine Addictologique, Paris, France.
  • Veerle Bergink
    Department of Psychiatry - Erasmus Medical Center, Rotterdam, the Netherlands; Department of Psychiatry, Department of Obstetrics, Icahn School of Medicine at Mount Sinai, New York, USA.
  • Andrea Fagiolini
    Dipartimento di Medicina Molecolare, Divisione di Psichiatria, Università di Siena.
  • John R Geddes
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.
  • Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada (Hajek, Cooke, Alda); Prague Psychiatric Centre/ National Institute of Mental Health, Prague, Czech Republic (Hajek, Kopecek, Novak, Hoschl, Alda); Charles University, 3rd Faculty of Medicine, Prague, Czech Republic (Kopecek, Novak, Hoschl, Alda).
  • Chantal Henry
    Department of Psychiatry, Service Hospitalo-Universitaire, GHU Paris Psychiatrie & Neurosciences, F-75014 Paris, France.
  • Ralph Kupka
    Amsterdam UMC, Vrije Universiteit, Department of Psychiatry, Amsterdam, Netherlands.
  • Trine V Lagerberg
    NORMENT, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
  • Rasmus W Licht
    Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; Psychiatry - Aalborg University Hospital, Aalborg, Denmark.
  • Monica Martinez-Cengotitabengoa
    Hospital Universitario de Alava. BIOARABA, UPV/EHU. CIBERSAM. Vitoria, Spain.
  • Gunnar Morken
    Østmarka Department of Psychiatry, St Olav University Hospital, Trondheim, Norway; Department of Mental Health, Faculty of Medicine and Healthsciences, Norwegian University of Science and Technology, Trondheim, Norway.
  • René E Nielsen
    Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; Psychiatry - Aalborg University Hospital, Aalborg, Denmark.
  • Ana Gonzalez Pinto
    Hospital Universitario de Alava. BIOARABA, UPV/EHU. CIBERSAM. Vitoria, Spain.
  • Andreas Reif
  • Marcella Rietschel
    Department of Genetic Epidemiology in Psychiatry, Institute of Central Mental Health, Medical Faculty Mannheim, University of Heidelberg.
  • Phillip Ritter
    Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Thomas G Schulze
    Institute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig-Maximilian University of Munich, Munich, Germany; Department of Psychiatry and Psychotherapy, Ludwig-Maximilian University of Munich, Munich, Germany; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland, USA; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.
  • Jan Scott
    Professor at the Academic Psychiatry, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
  • Emanuel Severus
    Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Aysegul Yildiz
    Dokuz Eylül University Department of Psychiatry, Izmir, Turkey.
  • Lars Vedel Kessing
    Psychiatric Center Copenhagen and University of Copenhagen, Faculty of Health and Medical Sciences, Denmark.
  • Michael Bauer
    Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus Medical Faculty, Technische Universität Dresden, Dresden, Germany.
  • Guy M Goodwin
    Department of Psychiatry, University of Oxford, Oxford, UK.
  • Ole A Andreassen
    NORMENT, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. Electronic address: o.a.andreassen@medisin.uio.no.

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