AIMC Topic: Bipolar Disorder
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An open dataset and machine learning algorithms for Niacin Skin-Flushing Response based screening of psychiatric disorders.
BMC psychiatry
Aug 4, 2025
BACKGROUND: Niacin Skin-Flushing Response (NSR) has emerged as a promising objective biomarker for the precise diagnosis of mental disorders. However, its diagnostic potential has been constrained by the limitations of traditional statistical approac...
Detecting schizophrenia, bipolar disorder, psychosis vulnerability and major depressive disorder from 5 minutes of online-collected speech.
Translational psychiatry
Jul 12, 2025
Psychosis poses substantial social and healthcare burdens. The analysis of speech is a promising approach for the diagnosis and monitoring of psychosis, capturing symptoms like thought disorder and flattened affect. Recent advancements in Natural Lan...
Different prefrontal cortex activity patterns in bipolar and unipolar depression during verbal fluency tasks based on functional near infrared spectroscopy study.
Scientific reports
Jul 1, 2025
This study aimed to investigate the functionality of the prefrontal cortex in patients with unipolar depression (UD) and bipolar depression (BD) using functional near-infrared spectroscopy (fNIRS) during a verbal fluency task (VFT). Additionally, it ...
Differences in resting-state functional connectivity between depressed bipolar and major depressive disorder patients: A machine learning study.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Jun 17, 2025
Nearly 60 % of individuals with bipolar disorder (BD) are initially classified as major depressive disorder (MDD) patients, resulting in inappropriate drug treatment. Identifying reliable biomarkers for the differential diagnosis between MDD and BD p...
Real-world effectiveness of cariprazine in major depressive disorder and bipolar I disorder in the United States.
Journal of medical economics
Jun 10, 2025
AIMS: The efficacy of cariprazine for major depressive disorder (MDD) (adjunctive therapy) and bipolar I (BP-I) depression has been demonstrated in clinical trials. This study evaluated the real-world effectiveness of cariprazine in reducing depressi...
Multivariate brain morphological patterns across mood disorders: key roles of frontotemporal and cerebellar areas.
BMJ mental health
Jun 10, 2025
BACKGROUND: Differentiating major depressive disorder (MDD) from bipolar disorder (BD) remains a significant clinical challenge, as both disorders exhibit overlapping symptoms but require distinct treatment approaches. Advances in voxel-based morphom...
Machine learning for classification of pediatric bipolar disorder with and without psychotic symptoms based on thalamic subregional structural volume.
BMC psychiatry
Jun 3, 2025
BACKGROUND: The thalamus plays a crucial role in sensory processing, emotional regulation, and cognitive functions, and its dysregulation may be implicated in psychosis. The aim of the present study was to examine the differences in thalamic subregio...
Using Digital Phenotyping to Discriminate Unipolar Depression and Bipolar Disorder: Systematic Review.
Journal of medical Internet research
May 23, 2025
BACKGROUND: Differentiating bipolar disorder (BD) from unipolar depression (UD) is essential, as these conditions differ greatly in their progression and treatment approaches. Digital phenotyping, which involves using data from smartphones or other d...
Machine learning based differential diagnosis of schizophrenia, major depression disorder and bipolar disorder using structural magnetic resonance imaging.
Journal of affective disorders
Apr 24, 2025
BACKGROUND: Cortical morphological abnormalities in schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BD) have been identified in past research. However, their potential as objective biomarkers to differentiate these disorde...
Joint resting state and structural networks characterize pediatric bipolar patients compared to healthy controls: a multimodal fusion approach.
NeuroImage
Apr 17, 2025
Pediatric bipolar disorder (PBD) is a highly debilitating condition, characterized by alternating episodes of mania and depression, with intervening periods of remission. Limited information is available about the functional and structural abnormalit...
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