A pendant droplet-based sensor for the detection of acetylcholinesterase and its inhibitors.

Journal: Chemical communications (Cambridge, England)
PMID: 35225993

Abstract

In this work, a pendant droplet-based sensor is developed for the rapid and label-free detection of acetylcholinesterase (AChE) and its inhibitors. The detection limit of AChE reaches 0.17 mU mL. The pIC values of AChE inhibitors such as neostigmine, rivastigmine and galantamine are determined to be 0.45 μM, 0.64 μM and 4.93 μM, respectively.

Authors

  • Benyou Li
    Key Laboratory of Colloid and Interface Chemistry, Shandong University, Ministry of Education, Jinan 250100, P. R. China. ylmlt@sdu.edu.cn.
  • Yongxian Guo
    School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, P. R. China. huqz@sdas.org.
  • Yifei Jiang
    Department of Chemistry, University of Washington, Seattle, Washington 98195, USA.
  • Jin-Ming Lin
    Beijing Key Laboratory of Microanalytical Methods and Instrumentation, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, China.
  • Qiongzheng Hu
    School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, P. R. China. huqz@sdas.org.
  • Li Yu
    Key Laboratory of Colloid and Interface Chemistry, Shandong University, Ministry of Education, Jinan 250100, P. R. China. ylmlt@sdu.edu.cn.

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