Butyrylcholinesterase (BChE) may serve as a scavenger enzyme protecting against various toxic compounds, but we still don't fully understand how it interacts with fentanyl analogues. We investigated how Despropionyl -methyl fentanyl (DPPM) inhibits e...
This research focuses on enhancing the extraction efficiency of Phylloporia ribis and assessing its biological functions. Key parameters including extraction temperature, duration, and ethanol-to-water ratio were optimized through both Response Surfa...
Traditional screening methods for acetylcholinesterase inhibitors (AChEIs) encounter significant challenges due to two primary factors: subjective errors in colorimetric analysis and reliance on laboratory instruments. To overcome these limitations, ...
In this study, in order to maximize the biological activity of Artemisia herba-alba Asso, extraction conditions were optimized by two different methods: Response Surface Methodology (RSM) and Artificial Neural Network-Genetic Algorithm (ANN-GA). A to...
BACKGROUND: The Inflation Reduction Act (IRA) did not introduce a cap on out-of-pocket (OOP) for newly approved Alzheimer's Disease (AD) drugs, such as lecanemab which is covered under Medicare Part B. Therefore, expanding the use of conventional ant...
Alzheimer's disease (AD) is a multifactorial neurological disorder accounting for the cognitive decline in the patients. The disease is linked to numerous pathological factors including hyperactivation of acetylcholinesterase (AChE) and monoamine oxi...
This study aims to determine the optimum extraction conditions that maximize the biological activities of Agaricus campestris and Agaricus bisporus species. In the study, a total of 64 extraction experiments were carried out at different temperatures...
OBJECTIVE: Alzheimer's disease poses a significant threat to human health. Currenttherapeutic medicines, while alleviate symptoms, fail to reverse the disease progression or reduce its harmful effects, and exhibit toxicity and side effects such as ga...
In this study, the biological activities of Otidea onotica were investigated using two optimization methods, Response Surface Methodology (RSM) and Artificial Neural Network-Genetic Algorithm (ANN-GA). The extracts were tested for phenolic content, a...
In this study, the biological activities of the extracts obtained under optimum extraction conditions of the kernel part of Juglans regia L. were determined. Two different methods, Response Surface Method (RSM) and Artificial Neural Network-Genetic A...
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