The deep learning model combining CT image and clinicopathological information for predicting ALK fusion status and response to ALK-TKI therapy in non-small cell lung cancer patients.

Journal: European journal of nuclear medicine and molecular imaging
PMID:

Abstract

PURPOSE: This study aimed to investigate the deep learning model (DLM) combining computed tomography (CT) images and clinicopathological information for predicting anaplastic lymphoma kinase (ALK) fusion status in non-small cell lung cancer (NSCLC) patients.

Authors

  • Zhengbo Song
    Department of Clinical Trial, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, 310022, Zhejiang, China.
  • Tianchi Liu
    School of Electrical and Electronic Engineering, Nanyang Technological University, Nanyang Avenue, 639798, Singapore. Electronic address: tcliu@ntu.edu.sg.
  • Lei Shi
  • Zongyang Yu
    Department of Medical Oncology, 900th Hospital, Fuzhou, 350000, Fujian, China.
  • Qing Shen
    Department of Clinical Laboratory, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, 324000, China.
  • Mengdi Xu
    Diannei Technology, Shanghai, China.
  • Zhangzhou Huang
    Department of Medical Oncology, Fujian Cancer Hospital, Fuzhou, 350001, China.
  • Zhijian Cai
    Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, 310009, Zhejiang, China.
  • Wenxian Wang
    Department of Clinical Trial, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, 310022, Zhejiang, China.
  • Chunwei Xu
    Department of Pathology, Fujian Cancer Hospital, Fuzhou, 350001, China.
  • Jingjing Sun
    School of Public Administration, Guangzhou University, Guangzhou, China.
  • Ming Chen
    Department of Critical Care Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.