Machine learning predicts stem cell transplant response in severe scleroderma.

Journal: Annals of the rheumatic diseases
PMID:

Abstract

OBJECTIVE: The Scleroderma: Cyclophosphamide or Transplantation (SCOT) trial demonstrated clinical benefit of haematopoietic stem cell transplant (HSCT) compared with cyclophosphamide (CYC). We mapped PBC (peripheral blood cell) samples from the SCOT clinical trial to scleroderma intrinsic subsets and tested the hypothesis that they predict long-term response to HSCT.

Authors

  • Jennifer M Franks
    Department of Molecular and Systems Biology.
  • Viktor Martyanov
    Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
  • Yue Wang
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
  • Tammara A Wood
    Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
  • Ashley Pinckney
    Rho Federal Systems Division, Chapel Hill, North Carolina, USA.
  • Leslie J Crofford
    Department of Medicine, Vanderbilt University Medical Center, 1161 21st Avenue South T3113 MCN, Nashville, TN, 37232, USA.
  • Lynette Keyes-Elstein
    Rho Federal Systems Division, Chapel Hill, North Carolina, USA.
  • Daniel E Furst
    Department of Medicine, Division of Rheumatology, University of California at Los Angeles, Los Angeles, California, USA.
  • Ellen Goldmuntz
    NIAID/NIH, Bethesda, Maryland, USA.
  • Maureen D Mayes
    Rheumatology and Clinical Immunogenetics, The University of Texas Health Science Center Houston Medical School, Houston, Texas, USA.
  • Peter McSweeney
    Rocky Mountain Blood and Marrow Transplant Program, Colorado Blood Cancer Institute, Denver, Colorado, USA.
  • Richard A Nash
    Rocky Mountain Blood and Marrow Transplant Program, Colorado Blood Cancer Institute, Denver, Colorado, USA.
  • Keith M Sullivan
    Duke University Medical Center, Durham, North Carolina, United States.
  • Michael L Whitfield
    Department of Molecular and Systems Biology.