AIMC Topic: Cyclophosphamide
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ShenJiaoLingCao decoction ameliorates cyclophosphamide-induced splenic injury and immunosuppression via the inhibition of MEK/ERK signaling pathway activity and modulation of amino acid metabolism.
Journal of ethnopharmacology
Apr 16, 2025
ETHNOPHARMACOLOGICAL RELEVANCE: ShenJiaoLingCao Decoction (SJLCD) is derived from the classic Chinese medicine prescription, which consists of ten kinds of herbs. In China, SJLCD has been used as an immunomodulator in clinical practice for more than ...
F-FDG PET radiomics score construction by automatic machine learning for treatment response prediction in elderly patients with diffuse large B-cell lymphoma: a multicenter study.
Journal of cancer research and clinical oncology
Mar 28, 2025
PURPOSE: To explore the development and validation of automated machine learning (AutoML) models for F-FDG PET imaging-based radiomics signatures to predict treatment response in elderly patients with diffuse large B-cell lymphoma (DLBCL).
Fluorodeoxyglucose F18
Prednisone
Rituximab
Vincristine
Prognosis
Treatment Outcome
Humans
Radiomics
Retrospective Studies
Radiopharmaceuticals
Machine Learning
Lymphoma, Large B-Cell, Diffuse
Positron-Emission Tomography
Female
Male
Cyclophosphamide
Aged
Middle Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols
Multi-stain deep learning prediction model of treatment response in lupus nephritis based on renal histopathology.
Kidney international
Dec 27, 2024
The response of the kidney after induction treatment is one of the determinants of prognosis in lupus nephritis, but effective predictive tools are lacking. Here, we sought to apply deep learning approaches on kidney biopsies for treatment response p...
Evaluation of external contamination on the vial surfaces of some hazardous drugs that commonly used in Chinese hospitals and comparison between environmental contamination generated during robotic compounding by IV: Dispensing robot vs. manual compounding in biological safety cabinet.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
Jun 24, 2021
OBJECTIVES: The aims of the study were to evaluate the external contamination of hazardous drug vials used in Chinese hospitals and to compare environmental contamination generated by a robotic intelligent dispensing system (WEINAS) and a manual comp...
Machine learning predicts stem cell transplant response in severe scleroderma.
Annals of the rheumatic diseases
Sep 15, 2020
OBJECTIVE: The Scleroderma: Cyclophosphamide or Transplantation (SCOT) trial demonstrated clinical benefit of haematopoietic stem cell transplant (HSCT) compared with cyclophosphamide (CYC). We mapped PBC (peripheral blood cell) samples from the SCOT...
Effect of inter-individual variability in human liver cytochrome P450 isozymes on cyclophosphamide-induced micronucleus formation.
Mutation research. Genetic toxicology and environmental mutagenesis
Dec 5, 2018
We investigated the relationship between metabolic activities of cytochrome P450 (CYP) isozymes present in microsomal fractions derived from the livers of 78 donors and micronucleus induction by cyclophosphamide (CPA). Consequently, a wide inter-indi...
Vitamin D deficiency and supplementation in patients with aggressive B-cell lymphomas treated with immunochemotherapy.
Cancer medicine
Dec 22, 2017
Vitamin D deficiency has been reported to be a negative prognostic factor in elderly patients with aggressive B-cell lymphomas. In vitro data suggest that vitamin D supplementation may enhance rituximab-mediated cytotoxicity. We prospectively assesse...
The use of natural language processing on narrative medication schedules to compute average weekly dose.
Pharmacoepidemiology and drug safety
Sep 16, 2016
PURPOSE: Medications with non-standard dosing and unstandardized units of measurement make the estimation of prescribed dose difficult from pharmacy dispensing data. A natural language processing tool named the SIG extractor was developed to identify...
Machine learning-based classification of diffuse large B-cell lymphoma patients by eight gene expression profiles.
Cancer medicine
Feb 11, 2016
Gene expression profiling (GEP) had divided the diffuse large B-cell lymphoma (DLBCL) into molecular subgroups: germinal center B-cell like (GCB), activated B-cell like (ABC), and unclassified (UC) subtype. However, this classification with prognosti...
Male
Middle Aged
Gene Expression Profiling
ROC Curve
Antineoplastic Combined Chemotherapy Protocols
Treatment Outcome
Support Vector Machine
Databases, Genetic
Doxorubicin
Survival Analysis
Prognosis
Female
Aged
Sensitivity and Specificity
Lymphoma, Large B-Cell, Diffuse
Humans
Genes, Neoplasm
Antibodies, Monoclonal, Murine-Derived
Germinal Center
Cyclophosphamide
Prednisone
Rituximab
Vincristine
Mutagenic Potential ofBos taurus Papillomavirus Type 1 E6 Recombinant Protein: First Description.
BioMed research international
Dec 9, 2015
Bovine papillomavirus (BPV) is considered a useful model to study HPV oncogenic process. BPV interacts with the host chromatin, resulting in DNA damage, which is attributed to E5, E6, and E7 viral oncoproteins activity. However, the oncogenic mechani...
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