MRI-based machine learning radiomics can predict HER2 expression level and pathologic response after neoadjuvant therapy in HER2 overexpressing breast cancer.

Journal: EBioMedicine
Published Date:

Abstract

BACKGROUND: To use clinical and MRI radiomic features coupled with machine learning to assess HER2 expression level and predict pathologic response (pCR) in HER2 overexpressing breast cancer patients receiving neoadjuvant chemotherapy (NAC).

Authors

  • Almir G V Bitencourt
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Imaging, A.C. Camargo Cancer Center, Sao Paulo, SP, Brazil.
  • Peter Gibbs
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Carolina Rossi Saccarelli
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Radiology, Hospital Sírio-Libanês, São Paulo, SP, Brazil.
  • Isaac Daimiel
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Roberto Lo Gullo
    Department of Radiology, Breast Imaging Service, Memorial Sloan Kettering Cancer Center, 300 E 66th Street, New York, NY, 10065, USA.
  • Michael J Fox
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Sunitha Thakur
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Katja Pinker
    Department of Radiology, Columbia University, Vagelos College of Physicians and Surgeons, New York, New York, USA.
  • Elizabeth A Morris
    Department of Radiology, Breast Imaging Service, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Monica Morrow
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Maxine S Jochelson
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.