Multicentre, deep learning, synthetic-CT generation for ano-rectal MR-only radiotherapy treatment planning.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Published Date: Nov 29, 2020

Abstract

BACKGROUND AND PURPOSE: Comprehensive dosimetric analysis is required prior to the clinical implementation of pelvic MR-only sites, other than prostate, due to the limited number of site specific synthetic-CT (sCT) dosimetric assessments in the literature. This study aims to provide a comprehensive assessment of a deep learning-based, conditional generative adversarial network (cGAN) model for a large ano-rectal cancer cohort. The following challenges were investigated; T2-SPACE MR sequences, patient data from multiple centres and the impact of sex and cancer site on sCT quality.

Authors

  • David Bird
    Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, United Kingdom; Radiotherapy Research Group, Leeds Institute of Medical Research, University of Leeds, United Kingdom. Electronic address: David.bird3@nhs.net.
  • Michael G Nix
    Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, United Kingdom.
  • Hazel McCallum
    Northern Centre for Cancer Care, Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom; Centre for Cancer, Newcastle University, United Kingdom.
  • Mark Teo
    Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, United Kingdom.
  • Alexandra Gilbert
    Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, United Kingdom; Radiotherapy Research Group, Leeds Institute of Medical Research, University of Leeds, United Kingdom.
  • Nathalie Casanova
    Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, United Kingdom.
  • Rachel Cooper
    Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, United Kingdom.
  • David L Buckley
    Biomedical Imaging, University of Leeds, United Kingdom.
  • David Sebag-Montefiore
    Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, United Kingdom; Radiotherapy Research Group, Leeds Institute of Medical Research, University of Leeds, United Kingdom.
  • Richard Speight
    Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, United Kingdom.
  • Bashar Al-Qaisieh
    Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, United Kingdom.
  • Ann M Henry
    Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, United Kingdom; Radiotherapy Research Group, Leeds Institute of Medical Research, University of Leeds, United Kingdom.

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