Deep Learning for Detecting Cerebral Aneurysms with CT Angiography.

Journal: Radiology
Published Date: Nov 3, 2020

Abstract

Background Cerebral aneurysm detection is a challenging task. Deep learning may become a supportive tool for more accurate interpretation. Purpose To develop a highly sensitive deep learning-based algorithm that assists in the detection of cerebral aneurysms on CT angiography images. Materials and Methods Head CT angiography images were retrospectively retrieved from two hospital databases acquired across four different scanners between January 2015 and June 2019. The data were divided into training and validation sets; 400 additional independent CT angiograms acquired between July and December 2019 were used for external validation. A deep learning-based algorithm was constructed and assessed. Both internal and external validation were performed. Jackknife alternative free-response receiver operating characteristic analysis was performed. Results A total of 1068 patients (mean age, 57 years ± 11 [standard deviation]; 660 women) were evaluated for a total of 1068 CT angiograms encompassing 1337 cerebral aneurysms. Of these, 534 CT angiograms (688 aneurysms) were assigned to the training set, and the remaining 534 CT angiograms (649 aneurysms) constituted the validation set. The sensitivity of the proposed algorithm for detecting cerebral aneurysms was 97.5% (633 of 649; 95% CI: 96.0, 98.6). Moreover, eight new aneurysms that had been overlooked in the initial reports were detected (1.2%, eight of 649). With the aid of the algorithm, the overall performance of radiologists in terms of area under the weighted alternative free-response receiver operating characteristic curve was higher by 0.01 (95% CI: 0.00, 0.03). Conclusion The proposed deep learning algorithm assisted radiologists in detecting cerebral aneurysms on CT angiography images, resulting in a higher detection rate. © RSNA, 2020 See also the editorial by Kallmes and Erickson in this issue.

Authors

  • Jiehua Yang
    From the School of Electronic Information and Communications, Huazhong University of Science and Technology, South 1st Building, Luoyu Road 1037, Wuhan 430074, China (J.Y., C.H., Y.X.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (M.X., O.A., J.L., T.J., X. Long); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (M.X., O.A., J.L., T.J., X. Long); Department of Radiology, Xin Cai People's Hospital, Xin Cai, China (Changde Li); and Huawei Technologies, Shenzhen, China (D.T., X. Liu, C.Z., Cixing Li).
  • Mingfei Xie
    From the School of Electronic Information and Communications, Huazhong University of Science and Technology, South 1st Building, Luoyu Road 1037, Wuhan 430074, China (J.Y., C.H., Y.X.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (M.X., O.A., J.L., T.J., X. Long); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (M.X., O.A., J.L., T.J., X. Long); Department of Radiology, Xin Cai People's Hospital, Xin Cai, China (Changde Li); and Huawei Technologies, Shenzhen, China (D.T., X. Liu, C.Z., Cixing Li).
  • Canpei Hu
    From the School of Electronic Information and Communications, Huazhong University of Science and Technology, South 1st Building, Luoyu Road 1037, Wuhan 430074, China (J.Y., C.H., Y.X.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (M.X., O.A., J.L., T.J., X. Long); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (M.X., O.A., J.L., T.J., X. Long); Department of Radiology, Xin Cai People's Hospital, Xin Cai, China (Changde Li); and Huawei Technologies, Shenzhen, China (D.T., X. Liu, C.Z., Cixing Li).
  • Osamah Alwalid
    From the School of Electronic Information and Communications, Huazhong University of Science and Technology, South 1st Building, Luoyu Road 1037, Wuhan 430074, China (J.Y., C.H., Y.X.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (M.X., O.A., J.L., T.J., X. Long); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (M.X., O.A., J.L., T.J., X. Long); Department of Radiology, Xin Cai People's Hospital, Xin Cai, China (Changde Li); and Huawei Technologies, Shenzhen, China (D.T., X. Liu, C.Z., Cixing Li).
  • Yongchao Xu
    From the School of Electronic Information and Communications, Huazhong University of Science and Technology, South 1st Building, Luoyu Road 1037, Wuhan 430074, China (J.Y., C.H., Y.X.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (M.X., O.A., J.L., T.J., X. Long); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (M.X., O.A., J.L., T.J., X. Long); Department of Radiology, Xin Cai People's Hospital, Xin Cai, China (Changde Li); and Huawei Technologies, Shenzhen, China (D.T., X. Liu, C.Z., Cixing Li).
  • Jia Liu
    Department of Colorectal Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Key Laboratory of Digestive Cancer, Tianjin, China.
  • Teng Jin
    From the School of Electronic Information and Communications, Huazhong University of Science and Technology, South 1st Building, Luoyu Road 1037, Wuhan 430074, China (J.Y., C.H., Y.X.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (M.X., O.A., J.L., T.J., X. Long); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (M.X., O.A., J.L., T.J., X. Long); Department of Radiology, Xin Cai People's Hospital, Xin Cai, China (Changde Li); and Huawei Technologies, Shenzhen, China (D.T., X. Liu, C.Z., Cixing Li).
  • Changde Li
    From the School of Electronic Information and Communications, Huazhong University of Science and Technology, South 1st Building, Luoyu Road 1037, Wuhan 430074, China (J.Y., C.H., Y.X.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (M.X., O.A., J.L., T.J., X. Long); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (M.X., O.A., J.L., T.J., X. Long); Department of Radiology, Xin Cai People's Hospital, Xin Cai, China (Changde Li); and Huawei Technologies, Shenzhen, China (D.T., X. Liu, C.Z., Cixing Li).
  • Dandan Tu
    From the School of Electronic Information and Communications, Huazhong University of Science and Technology, South 1st Building, Luoyu Road 1037, Wuhan 430074, China (J.Y., C.H., Y.X.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (M.X., O.A., J.L., T.J., X. Long); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (M.X., O.A., J.L., T.J., X. Long); Department of Radiology, Xin Cai People's Hospital, Xin Cai, China (Changde Li); and Huawei Technologies, Shenzhen, China (D.T., X. Liu, C.Z., Cixing Li).
  • Xiaowu Liu
    From the School of Electronic Information and Communications, Huazhong University of Science and Technology, South 1st Building, Luoyu Road 1037, Wuhan 430074, China (J.Y., C.H., Y.X.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (M.X., O.A., J.L., T.J., X. Long); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (M.X., O.A., J.L., T.J., X. Long); Department of Radiology, Xin Cai People's Hospital, Xin Cai, China (Changde Li); and Huawei Technologies, Shenzhen, China (D.T., X. Liu, C.Z., Cixing Li).
  • Changzheng Zhang
    From the School of Electronic Information and Communications, Huazhong University of Science and Technology, South 1st Building, Luoyu Road 1037, Wuhan 430074, China (J.Y., C.H., Y.X.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (M.X., O.A., J.L., T.J., X. Long); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (M.X., O.A., J.L., T.J., X. Long); Department of Radiology, Xin Cai People's Hospital, Xin Cai, China (Changde Li); and Huawei Technologies, Shenzhen, China (D.T., X. Liu, C.Z., Cixing Li).
  • Cixing Li
    From the School of Electronic Information and Communications, Huazhong University of Science and Technology, South 1st Building, Luoyu Road 1037, Wuhan 430074, China (J.Y., C.H., Y.X.); Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (M.X., O.A., J.L., T.J., X. Long); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (M.X., O.A., J.L., T.J., X. Long); Department of Radiology, Xin Cai People's Hospital, Xin Cai, China (Changde Li); and Huawei Technologies, Shenzhen, China (D.T., X. Liu, C.Z., Cixing Li).
  • Xi Long
    1Department of Electrical EngineeringEindhoven University of Technology5612AZEindhovenThe Netherlands.

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