Exploring the Underlying Mechanism of Shenyankangfu Tablet in the Treatment of Glomerulonephritis Through Network Pharmacology, Machine Learning, Molecular Docking, and Experimental Validation.

Journal: Drug design, development and therapy
PMID:

Abstract

PURPOSE: This study aimed to explore the underlying mechanisms of Shenyankangfu tablet (SYKFT) in the treatment of glomerulonephritis (GN) based on network pharmacology, machine learning, molecular docking, and experimental validation.

Authors

  • Meiling Jin
    Author Affiliations: College of Nursing, Consumer Health Informatics & Communication Laboratory (Ms Jin and Dr Kim), Research Institute of Nursing Science (Dr Kim), Seoul National University, Seoul, Republic of Korea.
  • Wenwen Ren
    Department of Nephrology, Beijing Ditan Hospital,Capital Medical University, Beijing, 100015, People's Republic of China.
  • Weiguang Zhang
    Department of Nephrology, Chinese People's Liberation Army General Hospital, Chinese People's Liberation Army Institute of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), National Clinical Research Center for Kidney Diseases, Beijing, 100853, People's Republic of China.
  • Linchang Liu
    Department of Nephrology, Chinese People's Liberation Army General Hospital, Chinese People's Liberation Army Institute of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), National Clinical Research Center for Kidney Diseases, Beijing, 100853, People's Republic of China.
  • Zhiwei Yin
    Department of Nephrology, Chinese People's Liberation Army General Hospital, Chinese People's Liberation Army Institute of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), National Clinical Research Center for Kidney Diseases, Beijing, 100853, People's Republic of China.
  • Diangeng Li
    Department of Academic Research, Beijing-Chaoyang Hospital, Capital Medical University, Beijing, 100020, People's Republic of China.