The prognostic value of automated coronary calcium derived by a deep learning approach on non-ECG gated CT images from Rb-PET/CT myocardial perfusion imaging.

Journal: International journal of cardiology
Published Date:

Abstract

BACKGROUND: Assessment of both coronary artery calcium(CAC) scores and myocardial perfusion imaging(MPI) in patients suspected of coronary artery disease(CAD) provides incremental prognostic information. We used an automated method to determine CAC scores on low-dose attenuation correction CT(LDACT) images gathered during MPI in one single assessment. The prognostic value of this automated CAC score is unknown, we therefore investigated the association of this automated CAC scores and major adverse cardiovascular events(MACE) in a large chest-pain cohort.

Authors

  • Mirthe Dekker
    Department of Vascular Surgery, University Medical Centre Utrecht, the Netherlands; Department of Cardiology, Amsterdam University Medical Centre, Amsterdam, the Netherlands. Electronic address: m.dekker-17@umcutrecht.nl.
  • Farahnaz Waissi
    Department of Vascular Surgery, University Medical Centre Utrecht, the Netherlands; Department of Cardiology, Amsterdam University Medical Centre, Amsterdam, the Netherlands.
  • Ingrid E M Bank
    From the Image Sciences Institute (S.G.M.v.V., N.L., M.A.V., I.I.), Departments of Radiology (B.K.V., T.L., P.A.d.J., W.B.V.), Experimental Cardiology (I.E.M.B.), and Radiotherapy (D.H.J.G.v.d.B.), and Imaging Division (H.M.V.), University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands; Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands (N.L.); Departments of Biomedical Engineering and Physics (S.G.M.v.V., I.I.) and Radiology and Nuclear Medicine (I.I.), and Amsterdam Cardiovascular Sciences (I.I.), Amsterdam University Medical Center, University of Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands (N.L.); Department of Cardiology, Meander Medical Center, Amersfoort, the Netherlands (I.E.M.B.); Department of Medicine, University of Mississippi Medical Center, Jackson, Miss (A.C.); and Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tenn (J.G.T., J.J.C.).
  • Ivana Išgum
    Department of Biomedical Engineering and Physics, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands.
  • Asbjørn M Scholtens
    Department of Nuclear Medicine, Meander Medical Centre, the Netherlands.
  • Birgitta K Velthuis
    From the Image Sciences Institute (S.G.M.v.V., N.L., M.A.V., I.I.), Departments of Radiology (B.K.V., T.L., P.A.d.J., W.B.V.), Experimental Cardiology (I.E.M.B.), and Radiotherapy (D.H.J.G.v.d.B.), and Imaging Division (H.M.V.), University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands; Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands (N.L.); Departments of Biomedical Engineering and Physics (S.G.M.v.V., I.I.) and Radiology and Nuclear Medicine (I.I.), and Amsterdam Cardiovascular Sciences (I.I.), Amsterdam University Medical Center, University of Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands (N.L.); Department of Cardiology, Meander Medical Center, Amersfoort, the Netherlands (I.E.M.B.); Department of Medicine, University of Mississippi Medical Center, Jackson, Miss (A.C.); and Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tenn (J.G.T., J.J.C.).
  • Gerard Pasterkamp
    Department of Experimental Cardiology, Utrecht University Medical Center, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.
  • Robbert J de Winter
    Department of Cardiology, Amsterdam University Medical Centre, Amsterdam, the Netherlands.
  • Arend Mosterd
    Dutch Network for Cardiovascular Research (Werkgroep Cardiologische centra Nederland), Utrecht, The Netherlands (A.T.L.F., A.M., L.B., R.d.N., J.H.C.).
  • Leo Timmers
    Department of Cardiology, St. Antonius hospital Nieuwegein, the Netherlands; Netherlands Heart Institute, Utrecht, the Netherlands.
  • Dominique P V de Kleijn
    Department of Vascular Surgery, University Medical Centre Utrecht, the Netherlands; Netherlands Heart Institute, Utrecht, the Netherlands.