AIMC Topic: Calcium

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Evaluating safe infrared neural stimulation parameters: Calcium dynamics and excitotoxicity thresholds in dorsal root ganglia neurons.

Journal of neuroscience methods
BACKGROUND: As a promising neural stimulation technique, infrared neural stimulation (INS) has recently gained significant attention due to its ability to stimulate neuronal activities without needing exogenous agents. NIR light is absorbed by water ...

Advanced SERSome-based artificial-intelligence technology for identifying medicinal and edible homologs.

Talanta
Medicinal and edible homologs (MEHs) offer significant preventive and therapeutic benefits for various diseases and health functions. However, the widespread application of MEHs faces significant challenges, particularly in quality control and rapid ...

Living Microalgae-Based Magnetic Microrobots for Calcium Overload and Photodynamic Synergetic Cancer Therapy.

Advanced healthcare materials
The combination of Ca overload and reactive oxygen species (ROS) production for cancer therapy offers a superior solution to the lack of specificity in traditional antitumor strategies. However, current therapeutic platforms for this strategy are pri...

Machine Learning-Driven Discovery of Structurally Related Natural Products as Activators of the Cardiac Calcium Pump SERCA2a.

ChemMedChem
A key molecular dysfunction in heart failure is the reduced activity of the cardiac sarcoplasmic reticulum Ca-ATPase (SERCA2a) in cardiac muscle cells. Reactivating SERCA2a improves cardiac function in heart failure models, making it a validated targ...

CaBind_MCNN: Identifying Potential Calcium Channel Blocker Targets by Predicting Calcium-Binding Sites in Ion Channels and Ion Transporters Using Protein Language Models and Multiscale Feature Extraction.

Journal of chemical information and modeling
Calcium ions (Ca) are crucial for various physiological processes, including neurotransmission and cardiac function. Dysregulation of Ca homeostasis can lead to serious health conditions such as cardiac arrhythmias and hypertension. Ion channels and ...

Machine learning enables high-throughput, low-replicate screening for novel anti-seizure targets and compounds using combined movement and calcium fluorescence in larval zebrafish.

European journal of pharmacology
Identifying new anti-seizure medications (ASMs) is difficult due to limitations in animal-based assays. Zebrafish (Danio rerio) serve as a model for chemical and genetic seizures, but current methods for detecting anti-seizure responses are limited b...

The calcitron: A simple neuron model that implements many learning rules via the calcium control hypothesis.

PLoS computational biology
Theoretical neuroscientists and machine learning researchers have proposed a variety of learning rules to enable artificial neural networks to effectively perform both supervised and unsupervised learning tasks. It is not always clear, however, how t...

A Graph-Based Machine-Learning Approach Combined with Optical Measurements to Understand Beating Dynamics of Cardiomyocytes.

Journal of computational biology : a journal of computational molecular cell biology
The development of computational models for the prediction of cardiac cellular dynamics remains a challenge due to the lack of first-principled mathematical models. We develop a novel machine-learning approach hybridizing physics simulation and graph...

Arithmetic abilities of SNP systems with astrocytes producing calcium.

Neural networks : the official journal of the International Neural Network Society
Are the membrane systems able of performing arithmetic operations? In the last dozen years, there were published several implementations of the arithmetic operations based on membrane systems by using all available topologies (cell-like, tissue-like,...