Constipation Predominant Irritable Bowel Syndrome and Functional Constipation Are Not Discrete Disorders: A Machine Learning Approach.

Journal: The American journal of gastroenterology
PMID: 32868630

Abstract

INTRODUCTION: Chronic constipation is classified into 2 main syndromes, irritable bowel syndrome with constipation (IBS-C) and functional constipation (FC), on the assumption that they differ along multiple clinical characteristics and are plausibly of distinct pathophysiology. Our aim was to test this assumption by applying machine learning to a large prospective cohort of comprehensively phenotyped patients with constipation.

Authors

  • James K Ruffle
    Centre for Neuroscience and Trauma, Blizard Institute, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, 26 Ashfield Street, London, E1 2AJ, UK.
  • Linda Tinkler
    Durham Bowel Dysfunction Service, University Hospital North Durham, County Durham and Darlington NHS Trust, Durham, United Kingdom.
  • Christopher Emmett
    Durham Bowel Dysfunction Service, University Hospital North Durham, County Durham and Darlington NHS Trust, Durham, United Kingdom.
  • Alexander C Ford
    Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, United Kingdom.
  • Parashkev Nachev
    Institute of Neurology, University College London, London, WC1N 3BG, UK.
  • Qasim Aziz
    Centre for Neuroscience and Trauma, Blizard Institute, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, 26 Ashfield Street, London, E1 2AJ, UK.
  • Adam D Farmer
    Centre for Neuroscience and Trauma, Blizard Institute, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, 26 Ashfield Street, London, E1 2AJ, UK.
  • Yan Yiannakou
    Durham Bowel Dysfunction Service, University Hospital North Durham, County Durham and Darlington NHS Trust, Durham, United Kingdom.

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