External validation of automated focal cortical dysplasia detection using morphometric analysis.

Journal: Epilepsia
PMID: 33638457

Abstract

OBJECTIVE: Focal cortical dysplasias (FCDs) are a common cause of drug-resistant focal epilepsy but frequently remain undetected by conventional magnetic resonance imaging (MRI) assessment. The visual detection can be facilitated by morphometric analysis of T1-weighted images, for example, using the Morphometric Analysis Program (v2018; MAP18), which was introduced in 2005, independently validated for its clinical benefits, and successfully integrated in standard presurgical workflows of numerous epilepsy centers worldwide. Here we aimed to develop an artificial neural network (ANN) classifier for robust automated detection of FCDs based on these morphometric maps and probe its generalization performance in a large, independent data set.

Authors

  • Bastian David
    Department of Epileptology, University Hospital Bonn, Bonn, Germany.
  • Judith Kröll-Seger
    Swiss Epilepsy Clinic, Klinik Lengg AG, Zurich, Switzerland.
  • Fabiane Schuch
    Department of Epileptology, University Hospital Bonn, Bonn, Germany.
  • Jan Wagner
    Department of Neurology, University Clinic Ulm, Ulm, Germany.
  • Jörg Wellmer
  • Friedrich Woermann
    Epilepsy Center Bethel, Mara Hospital & Society for Epilepsy Research, Bielefeld, Germany.
  • Bernhard Oehl
    Ortenau Klinikum, Offenburg, Germany.
  • Wim Van Paesschen
    Laboratory for Epilepsy Research, KU Leuven Biomedical Sciences Group, Leuven, Belgium.
  • Tobias Breyer
    Department of Radiology and Neuroradiology, Klinikum Dortmund, Dortmund, Germany.
  • Albert Becker
    Department of Neuropathology, University Hospital Bonn, Bonn, Germany.
  • Hartmut Vatter
    Department of Neurosurgery, University Hospital Bonn, Bonn, Germany.
  • Elke Hattingen
    Department of Neuroradiology, Johann Wolfgang Goethe University, Frankfurt, Germany.
  • Horst Urbach
    Department of Neuroradiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Bernd Weber
    Institute of Experimental Epileptology and Cognition Research, University of Bonn, Bonn 53113, Germany.
  • Rainer Surges
    Department of Epileptology, University Hospital Bonn, Bonn, Germany.
  • Christian Erich Elger
    Department of Epileptology, University Hospital Bonn, Bonn, Germany.
  • Hans-Jürgen Huppertz
    Swiss Epilepsy Centre, Klinik Lengg, Zurich, Switzerland.
  • Theodor Rüber
    Department of Epileptology, University Hospital Bonn, Bonn, Germany.

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