Low-dose PET image noise reduction using deep learning: application to cardiac viability FDG imaging in patients with ischemic heart disease.
Journal:
Physics in medicine and biology
PMID:
33524958
Abstract
INTRODUCTION: Cardiac [F]FDG-PET is widely used for viability testing in patients with chronic ischemic heart disease. Guidelines recommend injection of 200-350 MBq [F]FDG, however, a reduction of radiation exposure has become increasingly important, but might come at the cost of reduced diagnostic accuracy due to the increased noise in the images. We aimed to explore the use of a common deep learning (DL) network for noise reduction in low-dose PET images, and to validate its accuracy using the clinical quantitative metrics used to determine cardiac viability in patients with ischemic heart disease.