Artificial Intelligence-Enabled Assessment of the Heart Rate Corrected QT Interval Using a Mobile Electrocardiogram Device.

Journal: Circulation
Published Date: Feb 1, 2021

Abstract

BACKGROUND: Heart rate-corrected QT interval (QTc) prolongation, whether secondary to drugs, genetics including congenital long QT syndrome, and/or systemic diseases including SARS-CoV-2-mediated coronavirus disease 2019 (COVID-19), can predispose to ventricular arrhythmias and sudden cardiac death. Currently, QTc assessment and monitoring relies largely on 12-lead electrocardiography. As such, we sought to train and validate an artificial intelligence (AI)-enabled 12-lead ECG algorithm to determine the QTc, and then prospectively test this algorithm on tracings acquired from a mobile ECG (mECG) device in a population enriched for repolarization abnormalities.

Authors

  • John R Giudicessi
    Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
  • Matthew Schram
    AliveCor Inc., Mountain View, CA. (M.S., C.D.G., J.B.S., D.E.A.).
  • J Martijn Bos
    Department of Cardiovascular Medicine; Windland Smith Rice Sudden Death Genomics Laboratory, Department of Molecular Pharmacology and Experimental Therapeutics (J.M.B., M.J.A.), Mayo Clinic, Rochester, MN.
  • Conner D Galloway
    AliveCor Inc, Mountain View, California.
  • Jacqueline B Shreibati
    AliveCor Inc, Mountain View, California.
  • Patrick W Johnson
    Department of Health Sciences Research (Biomedical Statistics and Informatics), Mayo Clinic, Jacksonville, FL (P.W.J., R.E.C.).
  • Rickey E Carter
    Department of Health Sciences Research, Mayo Clinic, Jacksonville, Florida.
  • Levi W Disrud
    Division of Heart Rhythm Services, Windland Smith Rice Genetic Heart Rhythm Clinic (L.W.D., Z.I.A., P.A.N., P.A.F., M.J.A.), Mayo Clinic, Rochester, MN.
  • Robert Kleiman
    eResearch Technology Inc, Philadelphia, PA (R.K.).
  • Zachi I Attia
    Department of Cardiovascular Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
  • Peter A Noseworthy
    Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
  • Paul A Friedman
    Department of Cardiovascular Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
  • David E Albert
    AliveCor Inc, Mountain View, California.
  • Michael J Ackerman
    Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Keywords

External Resources

Popular Topics
Recent Journals