Prognostic Value of Serum Thyroglobulin Measured at 48 Hours Versus 72 Hours after Second Dose of Recombinant Human Thyrotropin in Surveillance of Well-Differentiated Thyroid Cancer.

Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Published Date: Dec 15, 2020

Abstract

OBJECTIVE: The sensitivity of thyroglobulin (Tg) to detect differentiated thyroid cancer recurrence increases with the rise of the thyrotropin level. Since 1998, recombinant human thyrotropin (rhTSH) has been commercially available for this purpose. The traditional protocol for using rhTSH calls for 2 daily injections of rhTSH, followed by the measurement of Tg 72 hours after the second dose. In this study, we compared the performance of rhTSH-stimulated Tg (rhTSH-Tg) obtained at 48 versus 72 hours after the second rhTSH.

Authors

  • Shirin Haddady
    School of Medicine, Boston University, Department of Medicine and Division of Endocrinology, Diabetes and Weight Management, Boston, Massachusetts. Electronic address: shirin.haddady@bmc.org.
  • Emma Pinjic
    Division of Rheumatology, Boston University School of Medicine, Boston, Massachusetts.
  • Stephanie L Lee
    School of Medicine, Boston University, Department of Medicine and Division of Endocrinology, Diabetes and Weight Management, Boston, Massachusetts.

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