MRI-Based Deep-Learning Method for Determining Glioma Promoter Methylation Status.

Journal: AJNR. American journal of neuroradiology
PMID: 33664111

Abstract

BACKGROUND AND PURPOSE: () promoter methylation confers an improved prognosis and treatment response in gliomas. We developed a deep learning network for determining promoter methylation status using T2 weighted Images (T2WI) only.

Authors

  • C G B Yogananda
    From the Advanced Neuroscience Imaging Research Lab (C.G.B.Y., B.R.S., S.S.N., G.K.M., F.F.Y., M.C.P., B.C.W., A.J.M., J.A.M.), Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas.
  • B R Shah
    From the Advanced Neuroscience Imaging Research Lab (C.G.B.Y., B.R.S., S.S.N., G.K.M., F.F.Y., M.C.P., B.C.W., A.J.M., J.A.M.), Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas.
  • S S Nalawade
    From the Advanced Neuroscience Imaging Research Lab (C.G.B.Y., B.R.S., S.S.N., G.K.M., F.F.Y., M.C.P., B.C.W., A.J.M., J.A.M.), Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas.
  • G K Murugesan
    From the Advanced Neuroscience Imaging Research Lab (C.G.B.Y., B.R.S., S.S.N., G.K.M., F.F.Y., M.C.P., B.C.W., A.J.M., J.A.M.), Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas.
  • F F Yu
    From the Advanced Neuroscience Imaging Research Lab (C.G.B.Y., B.R.S., S.S.N., G.K.M., F.F.Y., M.C.P., B.C.W., A.J.M., J.A.M.), Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas.
  • M C Pinho
    From the Advanced Neuroscience Imaging Research Lab (C.G.B.Y., B.R.S., S.S.N., G.K.M., F.F.Y., M.C.P., B.C.W., A.J.M., J.A.M.), Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas.
  • B C Wagner
    From the Advanced Neuroscience Imaging Research Lab (C.G.B.Y., B.R.S., S.S.N., G.K.M., F.F.Y., M.C.P., B.C.W., A.J.M., J.A.M.), Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas.
  • B Mickey
    Department of Neurological Surgery (B.M., T.R.P.), University of Texas Southwestern Medical Center, Dallas, Texas.
  • T R Patel
    Department of Neurological Surgery (B.M., T.R.P.), University of Texas Southwestern Medical Center, Dallas, Texas.
  • B Fei
    Department of Bioengineering (B.F.), University of Texas at Dallas, Richardson, Texas.
  • A J Madhuranthakam
    From the Advanced Neuroscience Imaging Research Lab (C.G.B.Y., B.R.S., S.S.N., G.K.M., F.F.Y., M.C.P., B.C.W., A.J.M., J.A.M.), Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas.
  • J A Maldjian
    From the Advanced Neuroscience Imaging Research Lab (C.G.B.Y., B.R.S., S.S.N., G.K.M., F.F.Y., M.C.P., B.C.W., A.J.M., J.A.M.), Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas joseph.maldjian@utsouthwestern.edu.

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