Initial dosing of intermittent vancomycin in adults: estimation of dosing interval in relation to dose and renal function.

Journal: European journal of hospital pharmacy : science and practice
Published Date: Aug 7, 2019

Abstract

OBJECTIVES: Due to the high interindividual variability in vancomycin pharmacokinetics, optimisation of its dosing is still challenging. This study aimed to explore vancomycin pharmacokinetics in adult patients and to propose an easy applicable dosing nomogram for initial treatment.

Authors

  • Martin Šíma
    Department of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic martin.sima@lf1.cuni.cz.
  • Jan Hartinger
    Department of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
  • Tomáš Grus
    2nd Department of Surgery - Department of Cardiovascular Surgery, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
  • Ondřej Slanař
    Department of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.

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