A deep learning system for detecting diabetic retinopathy across the disease spectrum.

Journal: Nature communications
Published Date: May 28, 2021

Abstract

Retinal screening contributes to early detection of diabetic retinopathy and timely treatment. To facilitate the screening process, we develop a deep learning system, named DeepDR, that can detect early-to-late stages of diabetic retinopathy. DeepDR is trained for real-time image quality assessment, lesion detection and grading using 466,247 fundus images from 121,342 patients with diabetes. Evaluation is performed on a local dataset with 200,136 fundus images from 52,004 patients and three external datasets with a total of 209,322 images. The area under the receiver operating characteristic curves for detecting microaneurysms, cotton-wool spots, hard exudates and hemorrhages are 0.901, 0.941, 0.954 and 0.967, respectively. The grading of diabetic retinopathy as mild, moderate, severe and proliferative achieves area under the curves of 0.943, 0.955, 0.960 and 0.972, respectively. In external validations, the area under the curves for grading range from 0.916 to 0.970, which further supports the system is efficient for diabetic retinopathy grading.

Authors

  • Ling Dai
    Department of Computer Science and Engineering, Shanghai Jiao Tong University, China; MoE Key Lab of Artificial Intelligence, AI Institute, Shanghai Jiao Tong University, China.
  • Liang Wu
    Clinical and Research Center of AIDS, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Huating Li
    Shanghai Jiao Tong University Affiliated Sixth People's Hospital, China. Electronic address: huarting99@sjtu.edu.cn.
  • Chun Cai
    Guangdong Provincial Engineering Research Center of Intelligent Low-carbon Pollution Prevention and Digital Technology & Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, School of Environment, South China Normal University, Guangzhou 510006, P. R. China.
  • Qiang Wu
    Department of Radiotherapy, West China Hospital, Sichuan University, Chengdu, PR China; Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, PR China.
  • Hongyu Kong
    Department of Ophthalmology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
  • Ruhan Liu
    Department of Computer Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
  • Xiangning Wang
    Department of Ophthalmology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
  • Xuhong Hou
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, 200233, China.
  • Yuexing Liu
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, 200233, China.
  • Xiaoxue Long
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, 200233, China.
  • Yang Wen
    Department of Computer Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
  • Lina Lu
    Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai Eye Diseases Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200040, China.
  • Yaxin Shen
    Department of Computer Science and Engineering, Shanghai Jiao Tong University, China; MoE Key Lab of Artificial Intelligence, AI Institute, Shanghai Jiao Tong University, China.
  • Yan Chen
    Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
  • Dinggang Shen
    School of Biomedical Engineering, ShanghaiTech University, Shanghai, China.
  • Xiaokang Yang
  • Haidong Zou
    Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China.
  • Bin Sheng
    MOE Key Laboratory of AI, School of Electronic, Information, and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, China.
  • Weiping Jia
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute Shanghai 200233, China.

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