Fully Automated MR Detection and Segmentation of Brain Metastases in Non-small Cell Lung Cancer Using Deep Learning.

Journal: Journal of magnetic resonance imaging : JMRI
Published Date:

Abstract

BACKGROUND: Non-small cell lung cancer (NSCLC) is the most common tumor entity spreading to the brain and up to 50% of patients develop brain metastases (BMs). Detection of BMs on MRI is challenging with an inherent risk of missed diagnosis.

Authors

  • Stephanie T Jünger
    Center for Neurosurgery, Department of General Neurosurgery, University of Cologne, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
  • Ulrike Cornelia Isabel Hoyer
    Institute for Diagnostic and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Diana Schaufler
    Department of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Network Genomic Medicine, Lung Cancer Group Cologne, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
  • Kai Roman Laukamp
    Institute for Diagnostic and Interventional Radiology, University Hospital Cologne, Cologne, Germany.
  • Lukas Goertz
    Institute for Diagnostic and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Frank Thiele
    Institute for Diagnostic and Interventional Radiology, University Hospital Cologne, Cologne, Germany.
  • Jan-Peter Grunz
    Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany. Electronic address: Grunz_J@ukw.de.
  • Marc Schlamann
    Institute for Diagnostic and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Michael Perkuhn
    Institute for Diagnostic and Interventional Radiology, University Hospital Cologne, Cologne, Germany.
  • Christoph Kabbasch
  • Thorsten Persigehl
    Institute for Diagnostic and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Stefan Grau
    Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne.
  • Jan Borggrefe
    Institute for Diagnostic and Interventional Radiology, University Hospital Cologne, Cologne, Germany. jan.borggrefe@uk-koeln.de.
  • Matthias Scheffler
    Department of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Network Genomic Medicine, Lung Cancer Group Cologne, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
  • Rahil Shahzad
    Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden PO Box 9600, 2300 RC, The Netherlands. Electronic address: r.shahzad@lumc.nl.
  • Lenhard Pennig
    Institute for Diagnostic and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Straße 62, 50937, Cologne, Germany.