Retinal photograph-based deep learning algorithms for myopia and a blockchain platform to facilitate artificial intelligence medical research: a retrospective multicohort study.

Journal: The Lancet. Digital health
PMID: 33890579

Abstract

BACKGROUND: By 2050, almost 5 billion people globally are projected to have myopia, of whom 20% are likely to have high myopia with clinically significant risk of sight-threatening complications such as myopic macular degeneration. These are diagnoses that typically require specialist assessment or measurement with multiple unconnected pieces of equipment. Artificial intelligence (AI) approaches might be effective for risk stratification and to identify individuals at highest risk of visual loss. However, unresolved challenges for AI medical studies remain, including paucity of transparency, auditability, and traceability.

Authors

  • Tien-En Tan
    Singapore Eye Research Institute, Singapore National Eye Centre.
  • Ayesha Anees
    Institute of High Performance Computing, A∗STAR, Singapore.
  • Cheng Chen
    Key Laboratory of Precision and Intelligent Chemistry, School of Chemistry and Materials Science, University of Science and Technology of China, China.
  • Shaohua Li
    Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai, 200072, P.R.China.tjdxsq@tongji.edu.cn.
  • Xinxing Xu
    A*STAR, Singapore, Singapore.
  • Zengxiang Li
    Institute of High Performance Computing, Agency for Science, Technology and Research (A*STAR), Singapore.
  • Zhe Xiao
    Institute of High Performance Computing, Agency for Science, Technology and Research (A*STAR), Singapore.
  • Yechao Yang
    Institute of High Performance Computing, Agency for Science, Technology and Research (A*STAR), Singapore.
  • Xiaofeng Lei
    Institute of High Performance Computing, Agency for Science, Technology and Research (A*STAR), Singapore.
  • Marcus Ang
    Singapore National Eye Centre, Singapore, Singapore.
  • Audrey Chia
    Singapore Eye Research Institute, Singapore, Singapore National Eye Centre, Singapore; Duke-National University of Singapore Medical School, Singapore.
  • Shu Yen Lee
    Singapore Eye Research Institute, Singapore National Eye Center, Singapore.
  • Edmund Yick Mun Wong
    Singapore Eye Research Institute, Singapore National Eye Center, Singapore.
  • Ian Yew San Yeo
    Singapore Eye Research Institute, Singapore, Singapore National Eye Centre, Singapore; Duke-National University of Singapore Medical School, Singapore.
  • Yee Ling Wong
    Saw Swee Hock School of Public Health, National University of Singapore, Singapore; Essilor International, Singapore.
  • Quan V Hoang
    Singapore Eye Research Institute, Singapore, Singapore National Eye Centre, Singapore; Duke-National University of Singapore Medical School, Singapore; Department of Ophthalmology, Columbia University, New York, NY, USA; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Ya Xing Wang
    Beijing Visual Science and Translational Eye Research Institute (BERI), Eye Center of Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China.
  • Mukharram M Bikbov
    Ufa Eye Research Institute, Ufa, Bashkortostan, Russia.
  • Vinay Nangia
    Suraj Eye Institute, Nagpur, India.
  • Jost B Jonas
    Department of Ophthalmology, Ruprecht-Karls University of Heidelberg, Heidelberg, Germany.
  • Yen-Po Chen
    Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
  • Wei-Chi Wu
    Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, 333. weichi666@gmail.com.
  • Kyoko Ohno-Matsui
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address: k.ohno.oph@tmd.ac.jp.
  • Tyler Hyungtaek Rim
    Department of Ocular Epidemiology, Singapore Eye Research Institute, Singapore, Singapore.
  • Yih-Chung Tham
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore.
  • Rick Siow Mong Goh
    A*STAR, Singapore, Singapore.
  • Haotian Lin
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou.
  • Hanruo Liu
  • Ningli Wang
  • Weihong Yu
    Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China yuweihongpumch@163.com.
  • Donald Tiang Hwee Tan
    Singapore Eye Research Institute, Singapore, Singapore National Eye Centre, Singapore; Duke-National University of Singapore Medical School, Singapore.
  • Leopold Schmetterer
    Singapore Eye Research Institute, Singapore National Eye Center, Duke-NUS Medical School, National University of Singapore, Singapore, Singapore.
  • Ching-Yu Cheng
    Singapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore.
  • Youxin Chen
    Department of Ophthalmology Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences Beijing People's Republic of China.
  • Chee Wai Wong
    Singapore National Eye Centre, Singapore.
  • Gemmy Chui Ming Cheung
    Singapore Eye Research Institute, Singapore National Eye Center, Singapore.
  • Seang-Mei Saw
  • Tien Yin Wong
    Singapore National Eye Center, Duke-National University of Singapore Medical School, Singapore 168751, Singapore; National Institutes of Health Research Biomedical Research Centre Biomedical Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.
  • Yong Liu
    Department of Critical care medicine, Shenzhen Hospital, Southern Medical University, Guangdong, Shenzhen, China.
  • Daniel Shu Wei Ting
    Singapore National Eye Center, Singapore Eye Research Institute Singapore Health Service Singapore Singapore.

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