Advanced Monte Carlo simulations of emission tomography imaging systems with GATE.

Journal: Physics in medicine and biology
Published Date:

Abstract

Built on top of the Geant4 toolkit, GATE is collaboratively developed for more than 15 years to design Monte Carlo simulations of nuclear-based imaging systems. It is, in particular, used by researchers and industrials to design, optimize, understand and create innovative emission tomography systems. In this paper, we reviewed the recent developments that have been proposed to simulate modern detectors and provide a comprehensive report on imaging systems that have been simulated and evaluated in GATE. Additionally, some methodological developments that are not specific for imaging but that can improve detector modeling and provide computation time gains, such as Variance Reduction Techniques and Artificial Intelligence integration, are described and discussed.

Authors

  • David Sarrut
    Université de Lyon, CREATIS, CNRS UMR5220, Inserm U1294, INSA-Lyon, Université Lyon 1, Lyon, France.
  • Mateusz Bała
    Jagiellonian University, Kraków, Poland.
  • Manuel Bardiès
    Centre Recherche en Cancérologie de Toulouse, Toulouse, France.
  • Julien Bert
    LaTIM, INSERM UMR 1101, IBRBS, Faculty of Medicine, Univ Brest, 22 avenue Camille Desmoulins, F-29238, Brest, France.
  • Maxime Chauvin
    CRCT, UMR 1037, INSERM, Université Toulouse III Paul Sabatier, Toulouse, France.
  • Konstantinos Chatzipapas
    Bioemission Technology Solutions (BIOEMTECH), Alexandras Av. 116, Athens, Greece.
  • Mathieu Dupont
    Aix-Marseille Univ, CNRS/IN2P3, CPPM, Marseille, France.
  • Ane Etxebeste
    Université de Lyon, CREATIS, CNRS UMR5220, Inserm U1294, INSA-Lyon, Université Lyon 1, Lyon, France.
  • Louise M Fanchon
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, United States of America.
  • Sébastien Jan
    Université Paris-Saclay, CEA, CNRS, Inserm, BioMaps, Service Hospitalier Frédéric Joliot, F-91401, Orsay, France.
  • Gunjan Kayal
    CRCT, UMR 1037, INSERM, Université Toulouse III Paul Sabatier, Toulouse, France.
  • Assen S Kirov
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, United States of America.
  • Paweł Kowalski
    High Energy Physics Division, National Centre for Nuclear Research, Otwock-Świerk, Poland.
  • Wojciech Krzemien
    High Energy Physics Division, National Centre for Nuclear Research, Otwock-Świerk, Poland.
  • Joey Labour
    Université de Lyon, CREATIS, CNRS UMR5220, Inserm U1294, INSA-Lyon, Université Lyon 1, Lyon, France.
  • Mirjam Lenz
    FH Aachen University of Applied Sciences, Forschungszentrum Jülich, Jülich, Germany.
  • George Loudos
    Bioemission Technology Solutions (BIOEMTECH), Alexandras Av. 116, Athens, Greece.
  • Brahim Mehadji
    Aix-Marseille Univ, CNRS/IN2P3, CPPM, Marseille, France.
  • Laurent Ménard
    Université Paris-Saclay, CNRS/IN2P3, IJCLab, F-91405 Orsay, France.
  • Christian Morel
    Aix-Marseille Univ, CNRS/IN2P3, CPPM, Marseille, France.
  • Panagiotis Papadimitroulas
  • Magdalena Rafecas
    Institute of Medical Engineering, University of Lübeck, Lübeck, Germany.
  • Julien Salvadori
    Department of Nuclear Medicine and Nancyclotep molecular imaging platform, CHRU-Nancy, Université de Lorraine, F-54000, Nancy, France.
  • Daniel Seiter
    Department of Medical Physics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, 53705, United States of America.
  • Mariele Stockhoff
    Department of Electronics and Information Systems, Medical Image and Signal Processing (MEDISIP), Ghent University, Ghent, Belgium.
  • Etienne Testa
    Univ. Lyon, Univ. Claude Bernard Lyon 1, CNRS/IN2P3, IP2I Lyon, F-69622, Villeurbanne, France.
  • Carlotta Trigila
    Department of Biomedical Engineering, University of California, Davis, CA 95616 United States of America.
  • Uwe Pietrzyk
    Faculty of Mathematics and Natural Sciences, University of Wuppertal, Wuppertal, Germany.
  • Stefaan Vandenberghe
    Department of Electronics and Information Systems, Medical Image and Signal Processing (MEDISIP), Ghent University, Ghent, Belgium.
  • Marc-Antoine Verdier
    Université Paris-Saclay, CNRS/IN2P3, IJCLab, F-91405 Orsay, France.
  • Dimitris Visvikis
    LaTIM, INSERM, UMR 1101, Brest 29609, France.
  • Karl Ziemons
    FH Aachen University of Applied Sciences, Forschungszentrum Jülich, Jülich, Germany.
  • Milan Zvolský
    Institute of Medical Engineering, University of Lübeck, Lübeck, Germany.
  • Emilie Roncali
    Department of Biomedical Engineering, University of California, Davis, United States of America.