Improved unsupervised physics-informed deep learning for intravoxel incoherent motion modeling and evaluation in pancreatic cancer patients.

Journal: Magnetic resonance in medicine
Published Date: Jun 9, 2021

Abstract

PURPOSE: Earlier work showed that IVIM-NET , an unsupervised physics-informed deep neural network, was faster and more accurate than other state-of-the-art intravoxel-incoherent motion (IVIM) fitting approaches to diffusion-weighted imaging (DWI). This study presents a substantially improved version, IVIM-NET , and characterizes its superior performance in pancreatic cancer patients.

Authors

  • Misha P T Kaandorp
    Department of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
  • Sebastiano Barbieri
    Centre for Big Data Research in Health, UNSW, Sydney, Australia.
  • Remy Klaassen
    Cancer Center Amsterdam, Department of Medical Oncology and LEXOR (Laboratory for Experimental Oncology and Radiobiology), Academic Medical Center, Amsterdam, The Netherlands.
  • Hanneke W M van Laarhoven
    Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
  • Hans Crezee
    Department of Radiation Oncology, Amsterdam University Medical Center, Amsterdam, The Netherlands.
  • Peter T While
    Department of Radiology and Nuclear Medicine, St. Olav's University Hospital, Trondheim, Norway.
  • Aart J Nederveen
    Departments of Radiology and Nuclear Medicine (C.P.S.B., A.J.N., P.v.O., R.N.P.) and Cardiology (S.M.B.), Amsterdam University Medical Centers, Location Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands; Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.M.W.); Department of Research and Development, Pie Medical Imaging BV, Maastricht, the Netherlands (J.P.A.); and Departments of Cardiology (G.P.B., S.A.J.C.) and Radiology (T.L.), University Medical Center Utrecht, Utrecht, the Netherlands.
  • Oliver J Gurney-Champion
    Joint Department of Physics, The Institute of Cancer Research, London, United Kingdom.

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