Choosing a Metamodel of a Simulation Model for Uncertainty Quantification.

Journal: Medical decision making : an international journal of the Society for Medical Decision Making
Published Date:

Abstract

BACKGROUND: Metamodeling may substantially reduce the computational expense of individual-level state transition simulation models (IL-STM) for calibration, uncertainty quantification, and health policy evaluation. However, because of the lack of guidance and readily available computer code, metamodels are still not widely used in health economics and public health. In this study, we provide guidance on how to choose a metamodel for uncertainty quantification.

Authors

  • Tiago M de Carvalho
    Department of Epidemiology and Biostatistics, Amsterdam UMC, Location VUMC, Amsterdam, the Netherlands.
  • Joost van Rosmalen
    Department of Epidemiology, Erasmus MC.
  • Harold B Wolff
    Department of Epidemiology and Biostatistics, Amsterdam UMC, Location VUMC, Amsterdam, the Netherlands.
  • Hendrik Koffijberg
    Department of Health Technology and Services Research, Technical Medical Centre, University of Twente, Enschede, The Netherlands. Electronic address: h.koffijberg@utwente.nl.
  • Veerle M H CoupĂ©
    Department of Epidemiology and Biostatistics, Amsterdam UMC, Location VUMC, Amsterdam, the Netherlands.