A Comparative Study of the Diagnostic Potential of Plasma and Erythrocytic α-Synuclein in Parkinson's Disease.

Journal: Neuro-degenerative diseases
PMID: 32485710

Abstract

BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disease characterized by intracellular α-synuclein (α-Syn) deposition. Alternation of the α-Syn expression level in plasma or erythrocytes may be used as a potential PD biomarker. However, no studies have compared their prognostic value directly with the same cohort.

Authors

  • Luxuan Wang
    School of Clinical Medicine, Ningxia Medical University, Yinchuan, China.
  • Guowei Wang
    School of Clinical Medicine, Ningxia Medical University, Yinchuan, China.
  • Yangyang Duan
    School of Clinical Medicine, Ningxia Medical University, Yinchuan, China.
  • Feng Wang
    Department of Oncology, Binzhou Medical University Hospital, Binzhou, Shandong, China.
  • Shaoqing Lin
    Department of Neurology, Brain Center of Sunshine Union Hospital, Sunshine Union Hospital, Weifang, China.
  • Fengting Zhang
    School of Clinical Medicine, Ningxia Medical University, Yinchuan, China.
  • Hui Li
    Department of Ophthalmology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
  • Andy Li
    Department of Pharmaceutical Sciences, Biomanufacturing Research Institute Biotechnology Enterprise (BRITE), North Carolina Central University, Durham, North Carolina, USA, pli@nccu.edu.
  • Haining Li
    Department of Neurology, General Hospital of Ningxia Medical University, Ningxia Key Laboratory of Cerebrocranial Diseases, Incubation Base of National Key Laboratory, Yinchuan, China.

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