An ultrafast and flexible liquid chromatography/tandem mass spectrometry system paves the way for machine learning driven in vivo sample processing in early drug discovery.

Journal: Rapid communications in mass spectrometry : RCM
Published Date: Jun 30, 2021

Abstract

RATIONALE: The low speed and low flexibility of most liquid chromatography/tandem mass spectrometry (LC/MS/MS) approaches in early drug discovery delay sample analysis from routine in vivo studies within the same day. A high-throughput platform for the rapid quantification of drug compounds in various in vivo assays was developed and established in routine bioanalysis.

Authors

  • Tim T Häbe
    Boehringer Ingelheim Pharma GmbH & Co. KG, Drug Discovery Sciences, Birkendorfer Strasse 65, Biberach an der Riss, 88397, Germany.
  • Christian Späth
    Boehringer Ingelheim Pharma GmbH & Co. KG, ISEE Infrastructure, Safety, Environment and Engineering, Birkendorfer Strasse 65, Biberach an der Riss, 88397, Germany.
  • Steffen Schrade
    Boehringer Ingelheim Pharma GmbH & Co. KG, Drug Discovery Sciences, Birkendorfer Strasse 65, Biberach an der Riss, 88397, Germany.
  • Wolfgang Jörg
    Boehringer Ingelheim Pharma GmbH & Co. KG, ISEE Infrastructure, Safety, Environment and Engineering, Birkendorfer Strasse 65, Biberach an der Riss, 88397, Germany.
  • Roderich D Süssmuth
    Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 124, Berlin, 10623, Germany.
  • Daniel Bischoff
    Boehringer Ingelheim Pharma GmbH & Co. KG, Drug Discovery Sciences, Birkendorfer Strasse 65, Biberach an der Riss, 88397, Germany.
  • Andreas H Luippold
    Boehringer Ingelheim Pharma GmbH & Co. KG, Drug Discovery Sciences, Birkendorfer Strasse 65, Biberach an der Riss, 88397, Germany.

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