Discriminating Heterogeneous Trajectories of Resilience and Depression After Major Life Stressors Using Polygenic Scores.

Journal: JAMA psychiatry

PMID: 33787853

Abstract

IMPORTANCE: Major life stressors, such as loss and trauma, increase the risk of depression. It is known that individuals show heterogeneous trajectories of depressive symptoms following major life stressors, including chronic depression, recovery, and resilience. Although common genetic variation has been associated with depression risk, genomic factors that could help discriminate trajectories of risk vs resilience following adversity have not been identified.

Authors

Katharina Schultebraucks

Department of Psychiatry, New York University School of Medicine, New York, NY, USA.
Karmel W Choi

Department of Psychiatry, Massachusetts General Hospital, Boston.
Isaac R Galatzer-Levy

Department of Psychiatry, NYU School of Medicine, New York, NY, USA. Isaac.Galatzer-Levy@nyumc.org.
George A Bonanno

Department of Counseling and Clinical Psychology, Teachers College, Columbia University, New York, New York, USA.

Keywords

Aged Deep Learning Depressive Disorder Female Genetic Predisposition to Disease Genome-Wide Association Study Humans Longitudinal Studies Male Middle Aged Multifactorial Inheritance Resilience, Psychological Stress, Psychological Supervised Machine Learning United States

External Resources

View on PubMed Access via DOI PubMed (33787853)

Discriminating Heterogeneous Trajectories of Resilience and Depression After Major Life Stressors Using Polygenic Scores.

Abstract

Authors

Keywords

External Resources

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