Physicochemical stability of nefopam and nefopam/droperidol solutions in polypropylene syringes for intensive care units.

Journal: European journal of hospital pharmacy : science and practice
PMID:

Abstract

INTRODUCTION: Nefopam has been reported to be effective in postoperative pain control with an opioid-sparing effect, but the use of nefopam can lead to nausea and vomiting. To prevent these side effects, droperidol can be mixed with nefopam. In intensive care units, high concentrations of nefopam and droperidol in syringes can be used with a continuous flow.

Authors

  • Elise D'Huart
    Pharmacy, Centre Hospitalier Universitaire de Nancy, Vandoeuvre-lès-Nancy, France.
  • Jean Vigneron
    Pharmacy, Centre Hospitalier Universitaire de Nancy, Vandoeuvre-lès-Nancy, France.
  • Igor Clarot
    Laboratoire CITHEFOR, Université de Lorraine, Nancy, France.
  • Béatrice Demoré
    Pharmacy, Centre Hospitalier Universitaire de Nancy, Vandoeuvre-lès-Nancy, France.