Stereotactic technology for 3D bioprinting: from the perspective of robot mechanism.

Journal: Biofabrication
Published Date: Aug 13, 2021

Abstract

Three-dimensional (3D) bioprinting has been widely applied in the field of biomedical engineering because of its rapidly individualized fabrication and precisely geometric designability. The emerging demand for bioprinted tissues/organs with bio-inspired anisotropic property is stimulating new bioprinting strategies. Stereotactic bioprinting is regarded as a preferable strategy for this purpose, which can perform bioprinting at the target position from any desired orientation in 3D space. In this work, based on the motion characteristics analysis of the stacked bioprinting technologies, mechanism configurations and path planning methods for robotic stereotactic bioprinting were investigated and a prototype system based on the double parallelogram mechanism was introduced in detail. Moreover, the influence of the time dimension on stereotactic bioprinting was discussed. Finally, technical challenges and future trends of stereotactic bioprinting within the field of biomedical engineering were summarized.

Authors

  • Baosen Tan
    Key Laboratory for Biomechanics and Mechanobiology of Chinese Education Ministry, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, People's Republic of China.
  • Shaolong Kuang
    Robotics and Micro-Systems Center, Soochow University, Suzhou City, Jiangsu Province, People's Republic of China. slkuang@suda.edu.cn.
  • Xiaoming Li
    Department of Radiology, Southwest Hospital, Third Military Medical University (Army Military Medical University), Chongqing, China.
  • Xiao Cheng
    Applied Technology College of Soochow University, Suzhou 215325, People's Republic of China.
  • Wei Duan
    School of Medicine, Deakin University, Victoria, Australia.
  • Jinming Zhang
    Key Laboratory for Biomechanics and Mechanobiology of Chinese Education Ministry, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, People's Republic of China.
  • Wenyong Liu
    c School of Biological Science and Medical Engineering , Beihang University , Beijing , China.
  • Yubo Fan
    State Key Laboratory of Software Development Environment, Key Laboratory of Biomechanics and Mechanobiology of Ministry of Education, Beihang University, Beijing, China. yubofan@buaa.edu.cn.

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