AIMC Topic: Tissue Scaffolds

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Hybrid additive manufacturing and data-guided design optimization for graded anterior cruciate ligament engineering.

Biomedical materials (Bristol, England)
Interface tissues, such as the enthesis connecting ligaments to bone, present multiphasic architectures with continuous gradients in structure, composition, and mechanics. Engineering such complex transitions remains a major challenge in biofabricati...

AI-powered printability evaluation framework for 3D bioprinting using Hausdorff distance metrics.

Biofabrication
3D bioprinting enables rapid fabrication of complex biological structures for tissue engineering applications. However, optimizing bioink formulation remains challenging due to complex relationships among material properties, printability, and cell v...

Decellularized tumor matrices as biomimetic cancer niche: a new perspective on cancer research and therapy.

Biomedical materials (Bristol, England)
Cancer is among the major causes of mortality, responsible for approximately 15% of all deaths worldwide. Despite remarkable progress in modern medicine, it remains a significant global health challenge. Nevertheless, conventional therapies such as c...

Functionalized mesenchymal stem cells for enhanced bone regeneration: advances and challenges.

Stem cell research & therapy
Bone fracture continues to pose a significant clinical challenge in regenerative medicine due to limited repair capacity and inadequate therapeutic options. Among the various therapeutic strategies, mesenchymal stem cells have shown strong potential ...

Alginate-based 3D bioprinting strategies for structure-function integrated tissue regeneration.

Journal of materials chemistry. B
Alginate-based biomaterials have been widely used for tissue repair and regeneration, owing to their tunability, biocompatibility, biodegradability, and low cytotoxicity. With the rapid advancement of bioprinting technology, alginate has increasingly...

Recellularization of scaffolds derived from precision-cut kidney slices.

Biomedical materials (Bristol, England)
The global rise in chronic kidney disease necessitates innovative solutions for end-stage renal disease that can help to overcome the limitations of the only available treatment options, transplantation and dialysis. Tissue engineering presents a pro...

A detailed guide to melt electro-writing for tissue engineering applications.

Biofabrication
Melt electro-writing (MEW) is an advanced 3D printing technique with significant potential in tissue engineering due to its ability to create highly precise microscale structures using biocompatible materials. This review provides a comprehensive gui...

Computational optimization of 3D printed bone scaffolds using orthogonal array-driven FEA and neural network modeling.

Scientific reports
Today, orthopedic surgeons have been continuously focusing on bone tissue engineering for regenerating damaged bone through the use of biomimetic scaffolds and innovative materials. Hence, this study presents a comprehensive investigation into the op...

Computer vision to predict cell seeding coverage in re-endothelialized mouse lungs.

Scientific reports
Transplantation of donor grafts recellularized with recipient-derived or non-immunogenic universal cells is a potential means of reducing the graft rejection and post-transplant complications in lung transplantation. Achieving a fully recellularized ...

Discovering novel type I collagen fragments from Cyprinus carpio supporting bone regeneration.

Functional & integrative genomics
Fish collagen is gaining increasing attention in tissue engineering due to its exceptional bioactivity. This study aimed to isolate functional fish collagen fragments capable of microbial biosynthesis and supporting bone tissue regeneration. Collagen...