AIMC Topic: Printing, Three-Dimensional

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Biofabrication of 3D bioprinted and organ-on-chip blood-brain barrier models using hCMEC/D3 for intranasal delivery of central nervous system therapeutics.

Biofabrication
The BBB remains a major obstacle to effective treatment of CNS disorders by limiting the entry of most therapeutics into the brain. The hCMEC/D3 is widely used as anin vitromodel to study BBB structure, permeability, and drug transport. In parallel, ...

Hybrid additive manufacturing and data-guided design optimization for graded anterior cruciate ligament engineering.

Biomedical materials (Bristol, England)
Interface tissues, such as the enthesis connecting ligaments to bone, present multiphasic architectures with continuous gradients in structure, composition, and mechanics. Engineering such complex transitions remains a major challenge in biofabricati...

AI-powered printability evaluation framework for 3D bioprinting using Hausdorff distance metrics.

Biofabrication
3D bioprinting enables rapid fabrication of complex biological structures for tissue engineering applications. However, optimizing bioink formulation remains challenging due to complex relationships among material properties, printability, and cell v...

Magnetic Programming-Assisted Ultrasonic Printing for In Situ Fabrication of Untethered Robots.

ACS applied materials & interfaces
Magnetic soft robots offer significant potential for biomedical applications, as recent advances in magnetic programming and 3D printing technologies have enabled the fabrication of increasingly complex and multifunctional structures. However, curren...

Artificial intelligence-enabled hydrogels: innovations and applications.

Journal of materials chemistry. B
Due to the excellent biocompatibility and adjustability, hydrogels have broadened their application in different fields, such as 3D printing, tissue engineering, drug delivery, and biosensing. However, traditional hydrogel research is confronted with...

Machine learning recovers corrupted pharmaceutical 3D printing formulation data.

International journal of pharmaceutics
Pharmaceutical 3D printing is an emerging digital manufacturing technology capable of autonomously producing personalised medicines. However, the same reliance on digital workflows that enables this innovation also introduces new vulnerabilities, mos...

Additive manufacturing of microneedles: a quality by design approach to clinical translation.

International journal of pharmaceutics
Transdermal drug delivery systems (TDDS) offer a painless and non-invasive route of administration but are limited by the skin barrier. Microneedles (MNs) have been shown to overcome this challenge and enable the delivery of small molecules, peptides...

Flexible joints performance assessment of additive manufacturing FDM 3D printed TPU.

PloS one
Given the increasing adoption of flexible 3D-printed joints in the field of robotics, it is essential to characterize the stiffness/spring coefficient and damping of printed specimens to understand the effects of various processing parameters and the...

Alginate-based 3D bioprinting strategies for structure-function integrated tissue regeneration.

Journal of materials chemistry. B
Alginate-based biomaterials have been widely used for tissue repair and regeneration, owing to their tunability, biocompatibility, biodegradability, and low cytotoxicity. With the rapid advancement of bioprinting technology, alginate has increasingly...