Feasibility evaluation of PET scan-time reduction for diagnosing amyloid-β levels in Alzheimer's disease patients using a deep-learning-based denoising algorithm.

Journal: Computers in biology and medicine
Published Date:

Abstract

PURPOSE: To shorten positron emission tomography (PET) scanning time in diagnosing amyloid-β levels thus increasing the workflow in centers involving Alzheimer's Disease (AD) patients.

Authors

  • Zhao Peng
    Department of Engineering and Applied Physics, School of Physics, University of Science and Technology of China, Hefei, Anhui, China.
  • Ming Ni
    Department of Orthopaedics, Chinese People's Liberation Army General Hospital (301 Hospital), 28 Fuxing Rd, 100853, Beijing, China.
  • Hongming Shan
  • Yu Lu
    Faw-volkswagen Automative Co., Changchun, China.
  • Yongzhe Li
    School of Nuclear Science and Technology, University of Science and Technology of China, Hefei, 230026, China.
  • Yifan Zhang
    Department of Food Science and Nutrition, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, Zhejiang 310058, China.
  • Xi Pei
    Department of Engineering and Applied Physics, School of Physics, University of Science and Technology of China, Hefei, Anhui, China.
  • Zhi Chen
    Duke University.
  • Qiang Xie
    Department of Nuclear Medicine, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China.
  • Shicun Wang
    Department of Nuclear Medicine, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China; Institute of Nuclear Medical Physics, University of Science and Technology of China, Hefei, 230026, China.
  • X George Xu
    Department of Engineering and Applied Physics, School of Physics, University of Science and Technology of China, Hefei, Anhui, China.