Subchondral Bone Length in Knee Osteoarthritis: A Deep Learning-Derived Imaging Measure and Its Association With Radiographic and Clinical Outcomes.

Journal: Arthritis & rheumatology (Hoboken, N.J.)
Published Date: Oct 29, 2021

Abstract

OBJECTIVE: To develop a bone shape measure that reflects the extent of cartilage loss and bone flattening in knee osteoarthritis (OA) and test it against estimates of disease severity.

Authors

  • Gary H Chang
    Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, 72 E. Concord Street, Evans 636, Boston, MA, 02118, USA.
  • Lisa K Park
    Boston University, Boston, Massachusetts.
  • Nina A Le
    Boston University, Boston, Massachusetts.
  • Ray S Jhun
    Boston University, Boston, Massachusetts.
  • Tejus Surendran
    Boston University, Boston, Massachusetts.
  • Joseph Lai
    Boston University, Boston, Massachusetts.
  • Hojoon Seo
    Boston University, Boston, Massachusetts.
  • Nuwapa Promchotichai
    Boston University, Boston, Massachusetts.
  • Grace Yoon
    Boston University, Boston, Massachusetts.
  • Jonathan Scalera
  • Terence D Capellini
    Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, 02138, USA.
  • David T Felson
    Section of Rheumatology, Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.
  • Vijaya B Kolachalama
    1Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA 02118 USA.

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