Design of lung nodules segmentation and recognition algorithm based on deep learning.

Journal: BMC bioinformatics
Published Date:

Abstract

BACKGROUND: Accurate segmentation and recognition algorithm of lung nodules has great important value of reference for early diagnosis of lung cancer. An algorithm is proposed for 3D CT sequence images in this paper based on 3D Res U-Net segmentation network and 3D ResNet50 classification network. The common convolutional layers in encoding and decoding paths of U-Net are replaced by residual units while the loss function is changed to Dice loss after using cross entropy loss to accelerate network convergence. Since the lung nodules are small and rich in 3D information, the ResNet50 is improved by replacing the 2D convolutional layers with 3D convolutional layers and reducing the sizes of some convolution kernels, 3D ResNet50 network is obtained for the diagnosis of benign and malignant lung nodules.

Authors

  • Hui Yu
    Engineering Technology Research Center of Shanxi Province for Opto-Electric Information and Instrument, Taiyuan 030051, China. 13934603474@nuc.edu.cn.
  • Jinqiu Li
    Department of Biomedical Engineering, Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin University, Tianjin, China.
  • Lixin Zhang
    State Key Laboratory of Bioreactor Engineering, East China University of Science of Technology, Shanghai, China.
  • Yuzhen Cao
    School of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin 300072, China.
  • Xuyao Yu
    Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin, China. yuxuyao@tju.edu.cn.
  • Jinglai Sun
    Department of Biomedical Engineering, Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin University, Tianjin, China. sunjinglai@tju.edu.cn.