Factor Xa inhibitors in clinical practice: Comparison of pharmacokinetic profiles.

Journal: Drug metabolism and pharmacokinetics
PMID: 32007354

Abstract

BACKGROUND: The anticoagulant actions of oral direct factor Xa (FXa) inhibitors can be inferred from their observed plasma concentrations; however, the steady-state pharmacokinetics (PK) of different FXa inhibitors have not been compared in clinically.

Authors

  • Eri Goto
    Department of Cardiology and Nephrology, Dokkyo Medical University, 880-Kitakobayashi, Mibu, Tochigi, 321-0293, Japan. Electronic address: elie9yhhngt@cronos.ocn.ne.jp.
  • Shigeo Horinaka
    Department of Cardiology and Nephrology, Dokkyo Medical University, 880-Kitakobayashi, Mibu, Tochigi, 321-0293, Japan. Electronic address: horinaka@dokkyomed.ac.jp.
  • Toshihiko Ishimitsu
    Department of Cardiology and Nephrology, Dokkyo Medical University, 880-Kitakobayashi, Mibu, Tochigi, 321-0293, Japan. Electronic address: ishimitu@dokkyomed.ac.jp.
  • Toru Kato
    Internal Medicine, NHO Tochigi Medical Center, 1-10-37 Naka-Tomatsuri, Utsunomiya, Tochigi, 320-8580, Japan. Electronic address: torumed3@gmail.com.

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